Pre Congress – Session 3 – 3

Biomarkers for organ damage

James Dear

Session Description

Central to clinical toxicology is the stratification of risk following exposure to potentially toxic agents. The liver is one of the organs most commonly injured as a result of drug toxicity, with paracetamol (acetaminophen) being the most common cause. In recent years, a number of new circulating biomarkers have been identified and tested in rodent and human paracetamol poisoning. These markers are mechanistic or have increased specificity/sensitivity and promise to transform patient care by targeting treatment to patients who stand most to gain and allowing early safe hospital discharge of low risk patients.

Learning Objectives

• Understand current biomarkers for liver toxicity – their strengths and limitations
• Be able to describe the potential advantages of using microRNAs as biomarkers
• Knowledge of which markers report liver cell necrosis and apoptosis

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