Biomarkers for organ damage
Central to clinical toxicology is the stratification of risk following exposure to potentially toxic agents. The liver is one of the organs most commonly injured as a result of drug toxicity, with paracetamol (acetaminophen) being the most common cause. In recent years, a number of new circulating biomarkers have been identified and tested in rodent and human paracetamol poisoning. These markers are mechanistic or have increased specificity/sensitivity and promise to transform patient care by targeting treatment to patients who stand most to gain and allowing early safe hospital discharge of low risk patients.
• Understand current biomarkers for liver toxicity – their strengths and limitations
• Be able to describe the potential advantages of using microRNAs as biomarkers
• Knowledge of which markers report liver cell necrosis and apoptosis