Concurrent Abstracts and Posters Wednesday October 14

13.15-14.15
Clinical Toxicology III

Jurriaanse Zaal

Kees Kramers/Hans Maurer (chairs)

13.15-13.27
104
Qualitative comparison of LC-MS and immunoassays in serum of emergency toxicological cases
Dolder , Patrick ; Liechti , Matthias ; Rentsch , Katharina (Basel, Switzerland)
13.27-13.39
162
Solanum torvum induced-immunocytotoxicity
Prof. Neuman , Manuela ; Dr. Verjee , Zul (Presenting author); M.Sc. Giesbrecht , Esther ; Stefan Dr., Cristiana (Toronto, Canada)
13.39-13:51
248
The benefits of High Resolution LCMS for monitoring baclofen and its metabolites
PhD Thibert, Valérie ; Labat, L. ; Marques, A.R. ; Duretz, B. ; Granger, B. ; Eysseric, H. ; Decleves, X. (Courtaboeuf cedex, France)
13:51-14.03
280
The Association of CYP3A5, CYP2C8 And ABCB1 Polymorphisms With Early Renal Injury In Chinese Liver Transplant Recipients Receiving tacrolimus
Tang , Jiangtao ; Shi , Yunying ; Li , Yi ; Liao , Yun ; Zhang , Junlong ; Wang , Lanlan (Chengdu, China)
14.03-14.15
082
In vitro and in vivo metabolism of the NPS methoxypiperamide (MeOP) studied by hyphenated mass spectrometry
PhD Meyer, Markus R. ; Holderbaum, Anna ; Maurer, Hans H. (Homburg, Germany)

13.15-14.15

Biologics

Van Weelde Zaal

Anders Asberg, Annick de Vries (chairs)

13.15-13.27
076
LC-MS/MS Quantification of bio-active Infliximab in serum using biotinylated-TNF-a and streptavidin magnetic beads for a target based pre-analytical sample purification.
MSc Amrani, Mohsin El ; Kleinnijenhuis, Anne ; Maarseveen, Erik van ; Broek, Marcel van den (Utrecht, The Netherlands)
13.27-13.39
251
Estimation of precision and accuracy of two population pharmacokinetics models of infliximab in patients with inflammatory bowel diseases.
PhD Más-Serrano, Patricio ; Nalda-Molina, R ; Boquera-Ferrer, ML ; Pastor, C ; Sempere, L ; Gutierrez, A ; Selva, J (Alicante, Spain)
13.39-13:51
094
Pharmacokinetic and Pharmacodynamic (PK/PD) Guided Eculizumab Treatment in Children with Hematopoietic Stem Cell Transplant-associated Thrombotic Microangiopathy (HSCT-TMA)
PhD Fukuda , Tsuyoshi ; PhD Mizuno , Kana ; MD Dixon , Bradley P. ; Kathman , Thelma ; Block , Mary ; PharmD, MBA Teusink BCPS, Ashley ; MD Gruppo , Ralph A. ; MBBS, PhD Davies MRCP, Stella M. ; PharmD, PhD Vinks FCP, Alexander A. ; MD Jodele , Sonata (Cincinnati, United States of America)
13:51-14.03
306
CYP3A phenotype associated to use of biologics and inflammatory state in patients with rheumatoid arthritis
Prof. Molden, Espen ; Wollmann, BM ; Syversen, S ; Lie, E ; Gjestad, C ; Mehus, L ; Kvien, TK ; Molden, E (Presenting author) (Oslo, Norway)
14.03-14.15
085
Determination of adalimumab, infliximab and etanercept trough levels: an assay comparison
drs. Bezooijen, Ji Sun van (Rotterdam, The Netherlands)

13.15-14.15
Immunosuppressive drugs: IV Mycophenolic acid

Ruys/Van Rijckevorsel Zaal

Michael Oellerich/Reinier van Hest (chairs)

13.15-13.27
143
Is there any interest for intracellular mycophenolic acid measurements in kidney transplant patients ?
Nguyen Thi, Minh Thuan ; Mourad, Michel ; Capron, Arnaud ; Musuamba Tshinanu, Flora ; Vincent, Marie-Françoise ; Wallemacq , Pierre (Presenting author) (Brussels, Belgium)
13.27-13.39
063
Pharmacokinetics of total and free mycophenolic acid in lupus nephrithis: preliminary report.
Pharm MSc Luszczynska , Paulina ; Pawinski , Tomasz ; Durlik , Magdalena ; Majchrzak , Jadwiga ; Sikorska , Katarzyna ; Jankowska , Aneta (Warsaw, Poland)
13.39-13:51
301
MPA trough concentration is influenced by concomitant immunosuppressant in heart transplant patients.
Dr Kunicki, Paweł K. ; Wróbel, Aleksandra ; Kowalska, Ewelina ; Jerzak-Wodzyńska, Grażyna (Warsaw, Poland)
13:51-14.03
303
The 4-hour-after-dose MPA concentration is useful for infection diagnosis in allo-renal recipients
BAI, YANGJUAN ; ZOU, Yuangao ; SHI, YUNYING ; Su, ZHENZHEN ; WANG, LANLAN (Chengdu, Sichuan , China)
14.03-14.15
207
IMPDH-MONITORING IN RENAL TRANSPLANT PATIENTS IMPROVED USING EX-VIVO ACTIVATED PBMC
Klaasen, Rolf ; Vethe, Nils Tore ; Bremer, Sara ; Hole, Kristine ; Berg, Christine ; Andersen, Anders Mikal ; Skauby, Morten ; Midtvedt, Karsten ; Bergan , Stein (Oslo, Norway)

13.15-14.15
New Sampling drugs III: miscellaneous

Van Beuningen Zaal

Jan Willem Alffenaar (chair)

13.15-13.27
010
Micro-sampling applications in Pharmacokinetic studies
prof.dr. Meesters, Roland J.W. (Bogota D.C., Colombia)
13.27-13.39
136
Limited sampling strategies for Therapeutic Drug Monitoring of Co-trimoxazole in the treatment of Multidrug-Resistant Tuberculosis
Dijkstra , Jacob Albert ; Alsaad , N.S.I. ; Akkerman , O.W. ; Lange , W.C.M. de ; Werf , T.S. van der ; Kosterink , J.G.W. ; Alffenaar , J.W.C. (Groningen, The Netherlands)
13.39-13:51
169
Study on the origin of methadone in exhaled breath particles
Prof Beck , Olof ; Ljungkvist , Göran ; Stein , Karina ; Danielsson , Åsa ; Agge , Agneta ; Friberg , Helena ; Viklund , Emilia ; Claesson , Annika ; Hammar , Oscar ; Andersson , Marianne ; Sandqvist , Sören ; Ullah , Shahid ; Olin , Anna-Cari (Stockholm, Sweden)
13:51-14.03
234
Microwave-assisted on-spot derivatization for the GC-MS based determination of polar low molecular weight molecules -amongst which gabapentin- in dried blood spots
Sadones , Nele ; Bever , E. van ; van Bortel , L. ; Lambert , W.E. ; Stove , C.P. (Ghent, Belgium)
14.03-14.15
254
Pharmacokinetic Experiment Design by Minimizing a Weighted Bayes Risk Overbound
Bayard , David ; Dr. Jelliffe , Roger (Presenting author); Kryshchenko , Alona ; Neely , Michael (Los Angeles, U.S.A.)

13.15-14.15
Pediatrics II

Schadee Zaal

Steven Leeder/John van den Anker (chairs)

13.15-13.27
140
Therapeutic Drug Profiles in Human Breast Milk: is there a risk to the nursing infant?
Dr. Colantonio , David ; Delaney , Sarah ; Dr. Ito , Shinya (Toronto, Canada)
13.27-13.39
217
Is Cefazolin 30 mg/kg insufficient for perioperative prophylaxis for neonates and infants undergoing cardiac surgery?
Dr. Cremers, Serge ; Saiman, Lisa ; Abildskov, Kirsten ; Corda, Rozelle (New York, United States of America)
13.39-13:51
288
Inpatient polypharmacy among children with leukemia or lymphoma receiving IV antibiotic therapy within the first year from diagnosis
Dr Constance, Jonathan ; Linakis, Matthew ; Roberts, Jessica ; Sherwin, Catherine ; Spigarelli, Michael (Presenting author) (Salt Lake, U.S.A.)
13:51-14.03
122
High albuterol plasma concentrations caused by fingerprick blood following inhalation on the ICU
dr. Winter, Brenda de ; Hoog, Matthijs de ; Vet, Nienke ; Dunk-Craaijo, Joke ; Koch, Birgit ; Wildt, Saskia de (Rotterdam, The Netherlands)
14.03-14.15
331
Effect of CYP2B6 516 GT polymorphism and pubertal maturation on the metabolism of efavirenz in pediatric HIV-infected patients.
Rakhmanina , Natella ; Rossi , S. ; Gordish –Dressman , H. ; Schaik , R.H.N. van ; Anker , John van den ; Williams , K. ; Capparelli , E. (Washington, U.S.A.)

13.20-14.05
Poster Session XIII

Willen Burger Foyer

Eric Franssen (chair)

13.20-13.25
266
Voriconazole clearance estimation using pharmacokinetic population modeling.
Metsu, David ; Lamoureux, LF ; Laffont, LMA ; Seraissol, SP ; Marquet, MP ; Gandia, GP ; Woillard, WJB (Toulouse, France)
13.25-13.30
276
TOXICOLOGICAL SAFETY ASSESSMENT OF NOVEL CARBOHYDRAZIDES: AN ANTITUBERCULAR AGENT
Dr. Mishra, Ravinesh ; Siddiqui, Anees A ; Husain, Asif ; Rashid, Mohd (Baddi (Solan), India)
13.30-13.35
299
Validation of a rilpivirine population pharmacokinetic (PK) model
Roelofsen , Eveline ; Wilms , E.B. ; Gelinck , L.B.S. ; Gras , L. ; Berge , M. van den ; Burger , D.M. ; Touw , D.J. (Den Haag, The Netherlands)
13.40-13.45
328
A comparison the pharmacokinetics of vancomycin administered to patients with sepsis as a bolus and continuous infusion
Pharm.D. Hurkacz , Magdalena ; Duszynska , Wieslawa ; Wieczorek , Monika ; Glowacka , Krystyna ; Wiela-Hojenska , Anna ; Kübler , Andrzej (Wroclaw, Poland)
13.45-13.50
080
Population pharmacokinetics of vancomycin in Japanese patients with continuous renal replacement therapy
Oda, Kazutaka ; Tanoue, Naomi ; Honda, Yoshiteru ; Jono, Hirofumi ; Nishi, Kazuhiko ; Saitoh, Hideyuki (Kumamoto, Japan)
13.50-13.55
106
Comparison of Isoniazid and Rifampicin exposure between intermittent and daily anti-tubercular regimen, in children with tuberculosis-An interim analysis
dr. Ranjalkar , Jaya ; Dr. Susan Mathew , Binu ; Dr. Philip Verghese , Valsan ; Dr. Bose , Anuradha ; Dr. Rose , Winsley ; Dr. Gupta , Dulari ; Dr. Mathew , Aswathy ; Dr. Sen , Sumalya ; Dr. Ernest , Kalpana ; Lavanya , S. ; Dr. H Fleming , Denise (Vellore, India)
13.55-14.00
115
Therapeutic Drug Monitoring of Rifampicin : An Indian experience.
Dr Tester, Ashavaid ; Chawla, Prerna K ; Lokhande, Rohan V ; Naik, Prasad R. ; Dherai, Alpa J ; Amale, Rohit A. ; Udwadia, Zarir F. ; Mahashur, Ashok A ; Soman, Rajeev (Mumbai, India)
14.00-14.05
161
Assessment of an HPLC-MS/MS method for quantitative determination of seven beta lactam antibiotics, tazobactam, ciprofloxacin and linezolid in human plasma.
A/Prof Norris, Ross ; Radovanovic, Mirjana ; Sandaradura, Indy ; Marriott, Deborah (Sydney, Australia)

13.20-14.05
Poster Session XIV

Willen Burger Foyer

Rob Aarnoutse (chair)

13.20-13.25
228
Intoxication of a young girl revealed the pitfalls of GHB rapid screening
Andrews , Louise ; Franken , L.G.W. ; Slooff , V.D. ; Wildt , S.N. de ; Koch , B.C.P. (Rotterdam, The Netherlands)
13.30-13.35
241
New method for determination of vitamin K1 and two forms of vitamin K2 (MK-4, MK-7) in human serum by HPLC
Dr. Klapkova, Eva ; Cepova, Jana ; Prusa, Richard (Prague, Czech Republic)
13.35-13.40
271
Validated UHPLC-Orbitrap MS analysis for determination of metoprolol and a-hydroxymetoprolol in serum for application in pharmacokinetics
PharmD Yska, Jan Peter ; Postma-Kunnen, Sjoukje ; Hommema, Gerard ; Koopmans, Sikke ; Wilffert, Bob ; Roon, Eric van (Leeuwarden, The Netherlands)
13.40-13.45
308
Development and validation of a fast and sensitive liquid chromatographic method with fluorescence detection for determination of Vitamin A in plasma samples. Clinical application in preterm infants.
Dr Bartoli, Antonella Natalia ; Broglia, Monica ; Garofoli, Francesca ; Mazzucchelli, Iolanda ; Villani, Paola ; Decembrino, Lidia (Pavia, Italy)
13.45-13.50
316
Online analysis of 25-OH-vitamin D2/D3 in plasma and serum with the Evoq Triple Quad
Dr. Baessmann, Carsten ; Martin, R. ; Slot, G. van’t ; Heijden, R van der (Presenting author) (Bremen, Germany)
13.50-13.55
325
Analytical validation of point of care analysis of lithium
MSc Staal , Steven (Enschede, The Netherlands)
13.55-14.00
326
Performance study using Medimate Mini-lab: professional versus patient-user outcomes in drug monitoring of lithium.

MSc Staal , Steven ; Ungerer, Mathijn ; Geerlings, Bart ; Stevens, A.W.M.M. ; Bartholomew, Jody ; Krabbe , Hans ; Kölling, Pieternel ; Movig , Kris (Enschede, The Netherlands)
14.00-14.05
329
Therapeutic drug monitoring: Lithium patient’s self-tests at home
MSc Staal , Steven ; Movig , Kris ; Ungerer, Mathijn ; Tellegen, Marian ; Krabbe , Hans (Enschede, The Netherlands)
14.05-14.10
502
Fully automated direct extraction and analysis of dried blood spots for the determination of four anti-epileptic drugs and two active metabolites
Velghe, Sofie ; Stove, Christophe P. (Gent, Belgium)

13.20-14.05
Poster Session XV

Willen Burger Foyer

Buendia Jefferson (chair)

13.20-13.25
097
Gene expression profiling to predict antidepressant response in major depressive disorder
Woo , Hye In ; Lim , Shinn-Won ; Myung , Woojae ; Kim , Doh Kwan ; Lee , Soo-Youn (Changwon, South-Korea)
13.25-13.30
165
CYP3A5 polymorphism and accumulation of indoxyl sulfate affect the rate of increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease
Suzuki, Yosuke ; Fujioka, T ; Muraya, N ; Sato, F ; Matsumoto, K ; Tanaka, R ; Sato, Y ; Ohno, K ; Mimata, H ; Kishino, S ; Itoh, H (Oita, Japan)
13.40-13.45
310
Over-anticoagulation with phenprocoumon associated with CYP2C9 polymorphism: a case example of integrated therapeutic drug monitoring and pharmacogenetics
Dr Zandvliet, Anthe ; Franssen, Eric ; Boerlage – van Dijk, Kirsten ; Haak, Eric (Amsterdam, The Netherlands)
13.45-13.50
320
Influence of CYP3A5 polymorphisms on tacrolimus pharmacokinetics in renal transplant recipients among Chinese population
Shi, Yunying ; Yan, Lin (Presenting author); Li, Yi ; Wang, Lanlan (Chengdu, China)
13.50-13.55
327
Possible contribution of inosine triphosphate pyrophosphatase gene polymorphisms to azathioprine therapy in children with Crohn’s Disease
Ohno, Masako ; Tajiri, Hitoshi (KOBE, Japan)
13.55-14.00
493
CYP3A4*22 allele is related to increased plasma levels of 4-hydroxytamoxifen and partially compensates for the inefficient CYP2D6 metabolic activation of tamoxifen
Prof. Antunes , Marina ; Oliveira , Vanessa ; Raymundo , Suziane ; Staudt , Dilana ; Gössling , Gustavo ; Mathy , Geneviève ; Wallemacq , Pierre ; Linden , Rafael ; Schwartsmann , Gilberto ; Haufroid , Vincent (Novo Hamburgo, Brazil)
14.00-14.05
495
Influence of CYP2D6 and CYP3A4 phenotypes, drug interactions and vitamin D status on tamoxifen biotransformation
Prof. Antunes , Marina ; Timm , Tatiana ; Raymundo , Suziane ; Oliveira , Vanessa ; Staudt , Dilana ; Gössling , Gustavo ; Wallemacq , Pierre ; Haufroid , Vincent ; Schwartsmann , Gilberto ; Linden , Rafael (Novo Hamburgo, Brazil)

14.30-15.30
Anti-infective drugs IV: Miscellaneous Anti-Infective agents

Van Weelde Zaal

Rob Aarnoutse/Anders Asberg (chairs)

14.30-14.42
279
Limited sampling strategies for monitoring of Ertapenem in MDR-TB patients
Rijn , Sander van ; Altena , R. van ; Akkerman , O. ; Proost , J.H. ; Lange , W.C.M. de ; Werf , T.S. van der ; Kosterink , J.G.W. ; Alffenaar , J.W.C. (Groningen, The Netherlands)
14.42-14.54
033
Antiretroviral Testing: Development and Validation of LC-MS/MS Assays in Unique Specimen Sources to Support Clinical Trials
Assistant Prof Marzinke, Mark ; Parsons, Teresa ; Seserko, Lauren ; Fuchs, Edward ; Hendrix, Craig (Baltimore, U.S.A.)
14.54-15.06
078
UPLC-MS/MS method for the simultaneous quantification of anti-HBV nucleos(t)ides analogues: entecavir, lamivudine, telbivudine and tenofovir in plasma of HBV infected patients.
PENSI, DEBORA ; De Nicolò, Amedeo ; Simiele, Marco ; Boglione, Lucio ; Tomasello, Cristina ; Di Perri, Giovanni ; D’Avolio, Antonio (TURIN, Italy)
15.06-15.18
142
Plasma Levels of Polymyxin B in Clinical Practice and Correlation with Clinical Outcomes
Dr. Kubin, Christine ; Nelson, Brian ; Zhu, Zhengxiang ; Yin, Michael ; Cremers, Serge (Presenting author) (New york, United States of America)
15.18-15.30
146
Unbound vancomycin concentrations in different patient populations: identification of factors that influence its protein binding.
Oyaert, Matthijs ; Spriet, Isabel ; Allegaert, Karel ; Smits, Anne ; Verhaegen, Jan ; Vermeersch, Pieter ; Pauwels, Steven (Leuven, Belgium)

14.30-15.30
Assays III

Van Beuningen Zaal

Daan Touw/Peter Zweipfenning (chairs)

14.30-14.42
179
EVALUATION OF THE EVEROLIMUS QMS® IMMUNOASSAY ON THE ABBOTT ARCHITECTTM ANALYSER
Outeda, Maria ; Salvador, P ; Otero, A ; López, A ; Martín, I (A Coruña, Spain)
14.42-14.54
202
DETERMINATION OF TIBOLONE IN HUMAN PLASMA BY A VALIDATED LC-MS/MS METHOD
Prof. Svinarov , Dobrin ; Kostova , K. ; Tasheva , M. ; Georgieva , D. ; Kasabova , L. (Sofia, Bulgaria)
14.54-15.06
275
Plasma Concentration Monitoring of Teriflunomide Using Dried Blood Spot Methodology With Liquid Chromatography/Tandem Mass Spectrometry
Dr Filali-Ansary, Aziz ; Lunven, C ; Turpault, S ; Beyer, Y-J ; O’Brien, A ; Delfolie, A ; Boyanova, N ; Sanderink, G-J ; Baldinetti, F (Alfortville, France)
15.06-15.18
321
Evaluation of the new Methotrexate CMIA assay on the Architect i2000SR
Florin, Lisa ; Lemahieu, Charlien ; Stove , Veronique (Gent, Belgium)
15.18-15.30
322
IgM interference in the Abbott iVanco immunoassay: a case report
Florin, Lisa ; Vantilborgh, Anna ; Pauwels, Steven ; Vanwynsberghe, Timothy ; Vermeersch, Pieter ; Stove , Veronique (Gent, Belgium)

14.30-15.30
Other II

Mees Zaal

Dario Cattaneo/Ross Norris (chairs)

14.30-14.42
121
Physician adherence to therapeutic drug monitoring recommendations on thiopurines
Luin , Matthijs van ; Banser , A. ; Groenen , M. ; Klein Tank , M.J.T. ; Essink , A.W.G. (De Bilt, The Netherlands)
14.42-14.54
156
TDM OF MIDAZOLAM AFTER IV OR INTRANASAL ADMINISTRATION USING A SIMULATED COMPUTER MODEL AND BISPECTRAL INDEX (BIS). A NEED FOR INDIVIDUALIZED THERAPY?
Bioq. Kravetz, Maria Cecilia ; Otamendi, Esteban ; Lazarowsky, Alberto ; Buontempo, Fabian ; Chiappetta, Diego A. ; Capria, Juan José ; Bramuglia, Guillermo F (Ciudad Autónoma de Buenos Aires, Argentina)
14.54-15.06
292
Determination of apixaban, dabigatran, edoxaban and rivaroxaban in human serum by UPLC-MS/MS – method development and validation
Lindahl, Sofia ; Dyrkorn, Roar ; Hegstad, Solfrid (Trondheim, Norway)
15.06-15.18
295
Identification of different patterns of dabigatran in vivo bioactivation in patients on maintenance anticoagulation therapy
Baldelli , Sara ; Dario , Cattaneo ; Perrone , V. ; Pignatelli , P. ; Clementi , E. (Milan, Italy)
15.18-15.30
336
Therapeutic drug monitoring of psychotropic drugs and mild opioid analgesics in elderly hip fracture patients at hospital admission
MSc Waade, Ragnhild Birkeland ; Ranhoff, Anette Hylen ; Hermann, Monica ; Martinsen, Mette Irene ; Molden, Espen (Oslo, Norway)

14.30-15.30
Pharmacogenetics III: Transplantation

Jurriaanse Zaal

Dennis Hesselink/Nicolas Picard (chairs)

14.30-14.42
188
A RANDOMISED-CONTROLLED TRIAL TO STUDY THE ADDITIVE VALUE OF CYP3A5 GENOTYPE-BASED TACROLIMUS DOSING IN LIVING-DONOR KIDNEY TRANSPLANTATION
Shuker , Nauras ; Bouamar , Rachida ; Schaik , Ron van ; Clahsen- van Groningen , Marian ; Damman , Jeffrey ; Baan , Carla ; Wetering , Jacqueline van de ; Rowshani , Ajda ; Weimar , Willem ; Gelder , Teun van ; Hesselink , Dennis (Rotterdam, The Netherlands)
14.42-14.54
307
Impact of CYP3A4*22, CYP3A5*1 and POR*28 polymorphisms on tacrolimus dose optimization and the outcome of kidney transplantation.
Elens , Laure ; Padullés , Ariadna ; Llaudó , Inés ; Gelder , Teun van ; Hesselink , Dennis A ; Torras , Joan ; Cruzado , Josep M ; Bestard , Oriol ; Colom , Helena ; Andreu , Franc ; Grinyó , Josep M ; Shaik , Ron van ; Lloberas , Núria (Bruxelles, Belgium)
14.54-15.06
037
A large candidate gene approach of the calcineurin pathway identifies two variants associated with the risk of serious infections in calcineurin inhibitors-treated renal transplants
Resident POUCHE, Lucie ; Koitka, Mathias ; Stojanova, Jana ; Woillard , Jean-Baptiste ; Monchaud, Caroline ; Villeneuve, Claire ; Essig, Marie ; Abraham, Julie ; Le Meur, Yannick ; Rerolle, Jean-Phillippe ; Kamar, Nassim ; Rostaing, Lionel ; Merville, Pierre ; Gandia, Peggy ; Bouchet, Stephane ; Pettersen, Britt ; Marquet, Pierre ; Picard, Nicolas (LIMOGES, France)
15.06-15.18
318
Impact of CYP3A genetic variants on the CYP3A activity marker 4ß-hydroxycholesterol
Hole, Kristine ; Gjestad, Caroline ; Heitmann, Kristine ; Bremer, Sara ; Molden, Espen (Oslo, Norway)
15.18-15.30
247
ABCG2 and CYP3A4 polymorphisms as a risk factors for developing adverse drug reactions in patients taking atorvastatin: a case-control study
Mirošević Skvrce, Nikica ; Ganoci, LG ; Šimić, IŠ ; Muačević Katanec, DMK ; Macolić Šarinić, VMŠ ; Ortner Hadžiabdić, MOH ; Božina, NB (Zagreb, Croatia)

14.30-15.30
Oncology II

Plate/ Van Der Vorm Zaal

Anna deFazio/Markus Joerger (chairs)

14.30-14.42
040
TDM of paclitaxel (PTX) reduces severe toxicity and maintains efficacy in advanced Non-Small Cell Lung Cancer (NSCLC): Results of a randomized study
Joerger , Markus ; Salamone , Salvatore J. ; von Pawel , Joachim ; Kraff , Stefanie ; Fischer , Juergen R. ; Eberhardt , Wilfried ; Gauler , Thomas Christoph ; Mueller , Lothar ; Reinmuth , Niels ; Reck , Martin ; Kimmich , Martin ; Mayer , Frank ; Kopp , Hans-Georg ; Behringer , Dirk M. ; Ko , Yon-Dschun ; Frueh , Martin ; Hilger , Ralf A. ; Roessler , Max ; Moritz , Berta ; Miller , Michael Craig ; Jaehde , Ulrich (St. Gallen, Switzerland)
14.42-14.54
126
THERE IS STRONG EVIDENCE THAT THERAPEUTIC MONITORING SHOULD BE MANDATORY FOR PATIENTS ON HIGH DOSE BUSULFAN REGARDLESS OF AGE
Tesfaye , Hundie ; Pospisilova , R ; Prusa, R ; Riha , J ; Formankova , R ; Sedlacek , P ; Janeckova , D ; Keslova , P ; Vydra , J ; Novakova , L (Prague, Czech Republic)
14.54-15.06
144
Inhibition of OCT-2, MATE1 and MATE-2K as a possible mechanism of drug interaction between pazopanib and cisplatin.
THOMAS, Fabienne ; Sauzay, Chloé ; White-Koning, Melanie ; Hennebelle, Isabelle ; Imbs, Diane-Charlotte ; Chatelut, Etienne (Toulouse cedex 9, France)
15.06-15.18
191
Genetic polymorphisms are predictive for survival of patients with advanced gastrointestinal stromal tumors treated with imatinib
Verboom , Michiel ; Kloth , Jacqueline ; Straaten , Tahar van der ; Swen , Jesse ; Sleijfer , Stefan ; Reyners , An ; Mathijssen , Ron ; Guchelaar , Henk-Jan ; Steeghs , Neeltje ; Gelderblom , Hans (Leiden, The Netherlands)
15.18-15.30
243
A novel and rapid homogeneous immunoassay for quantitation of gemcitabine in plasma as a tool for therapeutic dose management (TDM)
Baburina , Irina ; Kozo , D. ; Jarrah , J. ; Barrett , M. ; Williams , K. ; Courtney , J. ; Beumer , J.H. ; Peters , G.J. ; Honeywell , R.J. ; Salamone , S.J. (Presenting author) (Bethlehem Pa, United States of America)

14.35-15.30
Poster Session XVI

Willen Burger Foyer

Marilyn Huestis (chair)

14.40-14.45
235
ARK™ Pregabalin Assay on Beckman AU480 Analyzer
Kasper, Kenneth ; Orozco, A. ; Naranjo, G. ; Moon, B. ; Valdez, J. (Fremont, California, U.S.A.)
14.45-14.50
252
Urinary Ethyl Glucuronide vs. Urinary Ethanol as a Screening Tool in patients undergoing detoxification programmes
Boquera Ferrer, Maria Luz ; Candela Boix, M ; Pastor, C ; Fernández-Peinado, L ; Riera, G ; Selva, J ; Más-Serrano, P (Presenting author) (Alzira (Valencia), Spain)
14.50-14.55
105
Validation of a rapid liquid chromatography-tandem mass spectrometry assay for quantification of imatinib in hair samples.
Tré-Hardy, Marie ; Linden, Rafael ; Venzon Antunes, Marina ; Comparsi Wagner, Sandrine ; Vieira, Nathalia ; Leite, Renata ; Reginato, Fabiola ; Capra, Marcelo ; Fogliatto, Laura ; Wallemacq, Pierre (Bruxelles, Belgium)
14.55-15.00
264
LC/MS Analysis of Phytocannabinoids and their Metabolites in Urine, Oral Fluid and Blood
Dr. Doyle , Rory ; ph.d Cote , Linda ; ph.d Szczesniewski , Andre ; ph.d Frick , Lauren ; ph.d Cichelli , Julie (Hockessin, U.S.A.)
15.00-15.05
281
Clinical toxicology of potentially severe olanzapine intoxication
drs. Sportel , Esther ; Ijmker , Rein ; Movig , Kris (Presenting author) (Enschede, The Netherlands)
15.05-15.10
312
Fast and confident identification of drugs and their metabolites using ion trap LC-MSn analysis and a library of >4,500 compounds
Dr. Baessmann, Carsten ; Schneider, B. ; Kiehne, A. ; Goetz, S. ; Meyer, M. (Bremen, Germany)
15.10-15.15
317
Confident identification of drugs in urine and serum using high resolution QTOF mass spectrometry and new software tools
Dr. Baessmann, Carsten ; Decker, P. ; Drury, T. ; Wendt, K. ; Goetz, S. (Presenting author) (Bremen, Germany)
15.15-15.20
340
Beyond acetaminophen: Characterization of N-acetyl cysteine (NAC) interference on multiple analytes and implications for assessing liver function.
Dr. Beach, Lori ; Colantonio, David (Hamilton, Canada)
15.20-15.25
342
LC/MS/MS Quantitative Analysis of Steroids in Serum and Urine, and Evaluation and Comparison of Sample Preparation Techniques
Dr. Doyle , Rory ; ph.d Szczesniewski , Andre ; ph.d Cote , Linda ; ph.d Frick , Lauren ; ph.d Cichelli , Julie (Hockessin, U.S.A.)
15.25-15.30
343
LC/MS Quantitative Analysis of Fat Soluble Vitamins in Blood
Dr. Doyle , Rory ; ph.d Szczesniewski , Andre (Presenting author); ph.d Cote , Linda ; ph.d Frick , Lauren ; ph.d Cichelli , Julie (Hockessin, U.S.A.)

14.35-15.30
Poster Session XVII

Willen Burger Foyer

Pawel Kunicki (chair)

14.35-14.40
246
TDM OF TACROLIMUS IN KIDNEY TRANSPLANT PATIENTS – EFFICACY OF DOSE ADJUSTMENTS
Strojil, Jan ; Anzenbacher, Pavel ; Urbánek, Karel ; Orsag, Jiri ; Ptacnikova, Marie ; Krejci, Karel (Olomouc, Czech Republic)
14.40-14.45
278
A model for the description of drug accumulation and AUC estimation of cyclosporin A using the Mean Residence Time approach
Nolain , Patrick ; Debord, Jean ; Turlure , Pascal ; Marquet , Pierre ; Woillard , Jean-Baptiste (Presenting author) (Limoges, France)
14.45-14.50
283
External Evaluation of Published Population Pharmacokinetic Models of Cyclosporine in Adult Renal Transplant Recipients: What do we Learn?
Mao , Junjun ; Jiao , Zheng (Presenting author); Zhao , Chen-Yan ; Chen , Han-Chao ; Ding , Jun-Jie ; Zhong , Ming-Kang (Shanghai, China)
14.50-14.55
298
Monitoring MPA trough concentration in heart transplant patients.
Dr Kunicki, Paweł K. ; Wróbel, Aleksandra ; Kowalska, Ewelina ; Jerzak-Wodzyńska, Grażyna (Warsaw, Poland)
14.55-15.00
302
Combined LC-MS/MS analyis of tacrolimus, sirolimus, everolimus, cyclosporin A, mycophenolic acid and creatinine in dried blood spots
Dr. Koster , Remco ; Alffenaar , Jan-Willem ; Botma, Rixt ; Hoekstra, Alle Tjipke ; Greijdanus, Ben ; Uges, Donald ; Kosterink, Jos ; Touw, Daan (Groningen, The Netherlands)
15.00-15.05
315
Online analysis of immunosuppressants in whole blood with the Evoq Triple Quad
Dr. Baessmann, Carsten ; Martin, R. ; Meyer, M. (Presenting author) (Bremen, Germany)
15.05-15.10
337
A comparison of the pharmacokinetic parameters of mycophenolic acid (MPA) of the concentrations of the total and a free fraction in serum of patients with renal diseases
Pharm.D. Hurkacz , Magdalena ; Pondel , Joanna ; Hurkacz , Magdalena (Presenting author); Krajewska , Magdalena ; Augustyniak-Bartosik , Hanna ; Glowacka , Krystyna ; Pawinski , Tomasz ; Luszczynska , Paulina ; Klinger , Marian (Wroclaw, Poland)
15.10-15.15
194
The usefulness of tacrolimus trough concentration monitoring in renal transplant recipients
Chadli, Zohra ; Chaabane, Amel ; Ben Fredj, Nadia ; Ben Fadhel, Najeh ; Slama, Ahleme ; Boughattas, Naceur A ; Aouam, Karim (Presenting author) (Monastir, Tunisia)
15.20-15.25
216
Tacrolimus pharmacodynamics along the calcineurin pathway in Liver Transplant Patients
PharmD Noceti, Ofelia ; Esperon, Patricia ; Pouché, Lucie ; Gerona, Solange ; Lens, Daniela ; Picard, Nicolas ; Vital, Marcelo ; Touriño, Cristina ; Woillard, Jean-Baptiste ; Marquet, Pierre (Montevideo, Uruguay)
15.25-15.30
195
First Report of a Successful Pregnancy in an Everolimus Treated Heart Transplanted Patient: Neonatal Disappearence of Immunosuppressive Drugs
M.D. ELEFTHERIOU, GEORGIOS ; Fiocchi, Roberto ; Vittori, Claudia ; D’Elia, Emilia ; Sebastiani, Roberta ; Strobelt, Nicola ; Crippa, Alberto ; Freddi, Cristina (BERGAMO, Italy)

14.35-15.20
Poster Session XVIII

Willen Burger Foyer

Brenda de Winter (chair)

14.35-14.40
220
Prediction of acute rejection and infections after adult liver transplantation: Towards better characterisation of target exposure for immunisuppressive drugs
Musuamba Tshinanu, Flora ; Wallemacq, Pierre ; Brunet, Mercè (London, United Kingdom)
14.40-14.45
027
Long term non-compliance of digoxin – a case report
Prof.,MD, PhD, Grundmann , Milan ; md, phd Kacirova , Ivana (Ostrava, Czech Republic)
14.45-14.50
199
Population pharmacokinetic analysis of phenytoin in Egyptians with epilepsy
Prof EL Desoky , Ehab S. ; Shaik , Jafar ; Derendorf , H. (Assiut, Egypt)
14.50-14.55
223
Pharmacokinetics of paracetamol and glucuronide, sulphate and CYP2E1 mediated metabolites in morbidly obese and non-obese patients
Rongen, Anne van ; Peeters, M.Y. ; Boerma, D. ; Ramshorst, B. van ; Dongen, H.P.A. van ; Anker, J.N. van den ; Knibbe , Catherijne (Nieuwegein, The Netherlands)
14.55-15.00
291
Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment
Kim, AnHye ; Lee, Jongtae ; Chung, Hyewon ; Yu, Kyung-Sang ; Jang, In-Jin (Seoul , South-Korea)
15.00-15.05
347
AUC-targeted vancomycin dosing in term and pre-term neonates
Dr. Yamada , Walter ; PhD Schaiquevich , Paula ; M.D. Neely , Michael (Los Angeles Ca, United States of America)
15.05-15.10
311
Effect of carbamazepine on the CYP3A biomarker 4ß-hydroxycholesterol depends on dose rather than steady-state concentration
Gjestad, Caroline ; Molden, Espen (Oslo, Norway)
15.10-15.15
079
First results from standardized oral fluid contamination experiments using Diphenhydramine as a model substance
Neumann, Jasna ; Böttcher, Michael (Dessau-Rosslau, Germany)
15.15-15.20
084
Tramadol pharmacokinetics in exhaled breath, oral fluid and plasma
Dr Rosenborg , Staffan ; professor Beck , Olof (Stockholm, Sweden)
15.20-15.25
352
Toxicological screening of post mortem blood samples from unexplained deaths in the Amsterdam region from 2011-2014
Peter Zweipfenning

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