Concurrent Abstracts and Posters Tuesday October 13

13.15-14.15
Clinical Toxicology II: Toxicology cases

Jurriaanse Zaal

Vanessa Steenkamp (chair)

13.15-13.27
300
A case report: Suspected XTC intoxication with unsuspected guest!
Bachelor Schrijver, Karlo ; Bosman, Robert ; Franssen, Eric (Amsterdam, The Netherlands)
13.27-13.39
059
Acute kidney injury following Atripla overdose: A case report
Havenith, Thomas ; Oude Lashof, Astrid ; Visschers, Maarten ; Schippers, Jolanda ; Burger , David (Maastricht, The Netherlands)
13.39-13.51
491
Evaluation of the performance of an a priori population pharmacokinetic tool for vancomycine in premature neonates, as compared to clinician empirical dosing
Fourgeaud , J. ; Grine , J. ; Saint-Marcoux , F. ; Casagrande , K. ; Guigonis , v. ; Marquet , Pierre ; Dr. Woillard , Jean-Baptiste (Presenting author) (Limoges, France)
13:51-14.03
152
SIGNIFICANTLY DELAYED ELIMINATION OF METHOTREXATE IN ASSOCIATION WITH IMPAIRED RENAL FUNCTION IN A MAN WITH OSTEOSARCOMA NECESSITATING MORE EFFECTIVE INTERVENTION IN ADDITION TO LEUCOVORIN RESCUE THERAPY.
Tesfaye , Hundie ; Beyerova , M ; Jedlickova , B ; Korandova , A ; Linke , Z ; Becvarova , M ; Shimota , M (Prague, Czech Republic)
14.03-14.15
112
CHARACTERISTICS OF ACUTE INTOXICATIONS REPORTED TO THE DUTCH POISONS INFORMATION CENTER BY EMERGENCY DEPARTMENTS
PhD Rietjens , Saskia ; Zandee , Bianka ; Hondebrink , Laura ; Mulder-Spijkerboer , Henneke ; Vries , Irma de ; Meulenbelt , Jan (Utrecht, The Netherlands)

13.15-14.15
Anti-epileptic drugs

Schadee Zaal

David Berry/Philip Patsalos (chairs)

13.15-13.27
171
Influence of UGT2B7 gene polymorphism on lamotrigine and valproate serum concentrations
Klarica , Iva ; Lovric , Mila ; Hajnšek , Sanja ; Cajic , Ivana ; Božina , Nada (Zagreb, Croatia)
13.27-13.39
158
Characterization of the Exposure-Response Relationship of Lamotrigine in Children with Childhood Absence Epilepsy
Mizuno , Kana ; Fukuda , Tsuyoshi ; Dong , Min ; Capparelli , Edmund ; Vinks , Alexander ; Glauser , Tracy A. (Cincinnati Oh, U.S.A.)
13.39-13:51
100
Population pharmacokinetic modeling of levetiracetam in pediatric and adult epileptic patients using therapeutic drug monitoring data
Dr. Yano, Ikuko ; Ito, Satoko ; Hashi, Sachiyo ; Yonezawa, Atsushi ; Ikeda, Akio ; Matsubara, Kazuo (Kyoto, Japan)
13:51-14.03
190
High levetiracetam clearance in a patient with subarachnoid haemorrhage.
Dr Helldén , Anders ; Roshanisefat , Mitra ; assoc prof Bellander , Bo-Michael ; dr Fotoohi , Alan ; dr Roshanisefat , Homayoun ; prof Beck , Olof ; dr Helldén , Anders (Stockholm, Sweden)
14.03-14.15
086
Great clinical benefit from monitoring protein-unbound valproic acid plasma concentrations in selected patients
Luin , Matthijs van ; Klok , B. ; Jong , K. de ; Maat , M. de ; Wouden , E.A. van der ; Stalpers-Konijnenburg , S. ; Essink , A.W.G. (De Bilt, The Netherlands)

13.15-14.15
Immunosuppressive drugs III: Tacrolimus

Ruys/Van Rijckevorsel Zaal

Stein Bergan (chair)

13.15-13.27
053
Determination of unbound fraction of tacrolimus in plasma with LC-MS/MS
ing. Stienstra , Klaas ; Dapperen , A. van ; Sikma , M.A. ; Meulenbelt , J. ; Maarseveen , E.M. van (Utrecht, The Netherlands)
13.27-13.39
124
Assessment of correlation between hepatic tissue and blood Tacrolimus concentration determined by LC-MS/MS method in liver transplant recipients.
Dr Pawinski, Tomasz ; Bodnar-Broniarczyk, Magdalena ; Urbanowicz, Arkadiusz ; Durlik, Magdalena ; Majchrzak, Jadwiga ; Chmura, Andrzej (Warsaw, Poland)
13.39-13:51
103
NFAT-regulated cytokine expression during tacrolimus therapy early after transplantation
Bremer, Sara ; Kasbo, M ; Johansson, ED ; Vethe, NT ; Klaasen, R ; Line, P-D ; Midtvedt, K ; Skauby, M ; Bergan, S (Oslo, Norway)
13:51-14.03
074
Development of a library of human natural urinary peptides for biomarker discovery in kidney transplant recipients.
SAUVAGE, François-Ludovic ; PASSERON, Sébastien ; ESSIG, Marie ; MARQUET, Pierre (LIMOGES Cedex, France)
14.03-14.15
176
COMPUTER-ASSISTED DOSE INDIVIDUALIZING OF TACROLIMUS IMPROVE TARGET CONCENTRATION ACHIEVEMENT IN RENAL TRANSPLANT RECIPIENTS – A PROSPECTIVE RANDOMIZED STUDY
Prof Åsberg, Anders ; Størset, E ; Skauby, M ; Neely , Michael ; Bergan, S ; Bremer, S ; Midtvedt, K (Oslo, Norway)

13.15-14.15
New Sampling drugs II: alternative matrices

Van Beuningen Zaal

Olof Beck/Lisbeth Patteet (chairs)

13.15-13.27
049
Is there a place for oral fluid testing in therapeutic drug monitoring of antipsychotics?
Patteet, Lisbeth ; Maudens, Kristof ; Morrens, Manuel ; Sabbe, Bernard ; Neels, Hugo (Wilrijk, Belgium)
13.27-13.39
050
Are capillary dried blood spots applicable for therapeutic drug monitoring of common antipsychotics? A proof of concept
Patteet, Lisbeth ; Maudens, Kristof ; Stove, Christophe ; Lambert, Willy ; Morrens, Manuel ; Sabbe, Bernard ; Neels, Hugo (Wilrijk, Belgium)
13.39-13:51
062
Simultaneous Emtricabine and Tenofovir hair assay for adherence studies
Dr. Jiang, Hongfeng ; Robbins, Reuben ; Gouse, Hetta ; Warne, Patricia ; Joska, John ; Mtingeni, Yoliswa ; Remien, Robert ; Cremers, Serge (Presenting author) (New York City, United States of America)
13:51-14.03
065
Sampling the stratum corneum to quantify drug uptake from topical products
Dr Delgado Charro, Begoña ; Cordery, Sarah ; Shehab, Zaher ; Bunge, Annette ; Guy, Richard (Bath, United Kingdom)
14.03-14.15
239
May oral fluid analysis complement INR assay in the prevention of adverse events during warfarin therapy?
Tommaso, Lomonaco (Pisa, Italy)

13.15-14.15
Oncology I

Van Weelde Zaal

Jan Beumer/Jenny Martin (chairs)

13.15-13.27
029
Relationship between the oxycodone pharmacokinetics and serum interleukin-6 in cachectic cancer patients
Sato, Hikaru ; Naito, Takafumi ; Ishida, Takuya ; Ohnishi, Kazunori ; Kawakami, Junichi (Hamamatsu, Japan)
13.27-13.39
200
Effect of CYP3A4*22, CYP3A5*3 and CYP3A combined genotypes on Endoxifen serum concentrations in breast cancer patients using Tamoxifen
Sanchez-Spitman , Anabel Beatriz ; Swen , J.J. ; Gelderblom , A.J. ; Dezentjé , V. ; Guchelaar , H.J. (Leiden, The Netherlands)
13.39-13:51
227
A therapeutic drug monitoring protocol for imatinib in chronic myeloid leukemia patients: feasibility and integration with pharmacogenetics
Prof. Di Paolo, Antonello ; Galimberti, Sara ; Polillo, Marialuisa ; Baraté, Claudia ; Fontanelli, Giulia ; Lastella, Marianna ; Galeotti, Laura ; Ceccherini, Francesco ; Petrini, Mario ; Danesi, Romano (Pisa, Italy)
13:51-14.03
284
Simultaneous determination of nilotinib, imatinib, dasatinib and erlotinib by ultra-performance liquid chromatography with mass spectrometric detection
Chahbouni, Abdel (Amsterdam, The Netherlands)
14.03-14.15
039
Immunoassay-based therapeutic drug monitoring of 5-FU improves treatment of metastatic colorectal cancer (mCRC) patients
Salamone , Salvatore J. ; Kunzmann , Volker ; Link , Karin ; Miller , Michael Craig ; Holdenrieder , Stefan ; Bertsch , Thomas ; Mueller , Lothar ; Ko , Yon-Dschun ; Stoetzer , Oliver J ; Suttmann , Ingo ; Braess , Jan ; Jaehde , Ulrich ; Roessler , Max ; Moritz , Berta ; Kraff , Stefanie ; Fritsch , Achim ; Wilhelm , Martin (Bethlehem, United States of America)

13.20-14.10
Poster Session VII

Willen Burger Foyer

Johan Mouton (chair)

13.20-13.25
186
Bioavailability of voriconazole in hospitalized patients
MSc Veringa, Anette ; Alffenaar, Jan-Willem ; Geling, Sanne ; Vermeulen, Karin ; Zijlstra, Jan ; Span, Lambert ; Werf, Tjip van der ; Kosterink, Jos (Groningen, The Netherlands)
13.25-13.30
189
Identification and Quantification of Ampicillin, Cefazoline, Ceftriaxone, Ciprofloxacin, Daptomycin, Levofloxacin, Linezolid, Meropenem, Moxifloxacin, Piperacillin and Rifampicin in Plasma for Therapeutic Drug Monitoring Purposes-Development and Validation of a LC-MS/MS procedure
Rudolph, Wiebke ; Remane , Daniela ; Peters, Frank T. (Jena, Germany)
13.30-13.35
198
Safety and pharmacokinetics of daptomycin in Japanese patients
Ando, Motozumi ; Kobiki, Eriko ; Nakasako, Shinji ; Kashiwagi, Hiroko ; Kitada, Noriaki ; Morimoto, Shigehumi ; Kamei, Hiroki ; Sono, Yumi ; Nishioka, Hiroaki ; Fukuda, Tsuyoshi ; Hashida, Tohru (Kobe, Japan)
13.35-13.40
210
TDM-guided management in patients with Daptomycin
Yamada, Tomoyuki ; Suzuki, Kaoru ; Ooi, Yukimasa ; Nakano, Takashi ; Nishihara, Masami ; Katsumata, Takahiro ; Tamai, Hiroshi ; Ukimura, Akira (Osaka, Japan)
13.40-13.45
222
Atazanavir and cristalluria: all patients are concerned.
Lefeuvre, Sandrine ; Venisse, Nicolas ; BRET, LAURENT ; PRAZUCK, THIERRY ; BOIS, JULIE ; NIANG, MOHAMADOU ; GOT, LAURENCE ; HOCQUELOUX, LAURENT (Orléans, France)
13.45-13.50
225
The effect of inflammation on voriconazole trough concentrations in children
Avest, Mendy ter ; Veringa, Anette ; Kosterink, Jos ; Schölvinck, Elisabeth ; Tissing, Wim ; Alffenaar, Jan Willem (Groningen, The Netherlands)
13.50-13.55
497
Clinical evaluation of a dried blood spot method for determination of imatinib in chronic myeloid leukemia patients
Prof. Linden, Rafael ; Raymundo, Suziane ; Vieira, Natalia ; Fogliatto, Laura ; Wagner, Sandrine ; Capra, Marcelo ; Reginatto, Fabíola (Novo Hamburgo, Brazil)
14.00-14.05
245
Interoccasion variability of gentamicin peak concentrations in critically ill patients, do we need multiple measurements?
Janssen, Julie ; Hodiamont, C.J. ; Mathot, R.A. ; Juffermans, N.P. ; Hest, R.M. van (Amsterdam, The Netherlands)
14.05-14.10
255
Tenofovir disoproxil treatment for a HIV-HBV co-infected patient undergoing peritoneal dialysis.
MSc Aleman , Jacomien ; Berk , G.E.L. van de ; Fijter , C.W.H. de ; Franssen , E.J.F. (Amsterdam, The Netherlands)

13.20-14.15
Poster Session VIII

Willen Burger Foyer

Christoph Hiemke (chair)

13.20-13.25
077
Stabilized sensing of heparin in blood using heparin-imprinted electrode by surface modification or washing
Prof. Yoshimi, Yasuo ; Inaba, Ryo ; Ogawa, Takaya ; Inoue, Masaru ; Kuwana, Katsuyuki (Tokyo, Japan)
13.25-13.30
072
Fluorometric UHPLC method using NBD-F for quantitation of pregabalin in human plasma
Yoshikawa, Nozomi ; Naito, Takafumi ; Yagi, Tatsuya ; Kawakami, Junichi (Hamamatsu, Japan)
13.30-13.35
130
DETERMINATION OF IBANDRONIC ACID IN HUMAN PLASMA BY A VALIDATED LC-MS/MS METHOD
Prof. Svinarov , Dobrin ; Kostova , K. ; Tasheva , M. ; Georgieva , D. ; Kasabova , L. (Sofia, Bulgaria)
13.35-13.40
131
Too good to be true? Sample preparation of pemirolast in plasma using solid phase extraction with self-correcting dilution.
Lic. Med Sc Ackehed, Gerd ; Gambell Barroso, Miguel ; Östervall, Jennie ; Nilsson, Karin ; Pohanka, Anton (Stockholm, Sweden)
13.40-13.45
137
Quantification of Co-trimoxazole in serum and plasma using tandem mass spectrometry
Dijkstra , Jacob Albert ; Alsaad , N.S.I. ; Hateren , K. van ; Greijdanus , B. ; Touw , Daan ; Alffenaar , J.W.C. (Groningen, The Netherlands)
13.45-13.50
151
Improved determination of uracil and dihydrouracil in plasma after a loading oral dose of uracil using high-performance liquid chromatography with photodiode array detection and porous graphitic carbon stationary phase
Prof. Linden, Rafael ; Hahn, Roberta ; Galarza, Andrés ; Schneider, Anelise ; Antunes, Marina ; Schwartsmann, Gilberto (Novo Hamburgo, Brazil)
13.50-13.55
153
A fast LC-MS/MS method for analysis of phosphatidylethanol (PEth) to determine alcohol consumption
Wassenaar , Sophie ; Nagel , B.C.H. van der ; Stuyver , L.I. ; Schneider , A.J. ; Sibbles-van Genderen , B.J. ; Aaldriks , A. ; Faassen , E.E.H. van ; Koch , B.C.P. (Rotterdam, The Netherlands)
13.55-14.00
203
HPLC method for valsartan determination in human plasma
Msc Waś, Joanna ; Kunicki, Paweł K. ; Kowalska, Ewelina ; Wróbel, Aleksandra (Warsaw, Poland)
14.00-14.05
211
Determination of plasma concentration of dabigatran by liquid chromatography coupled with time of flight type single mass spectrometry
Nagano, Daisuke ; Araki, Takuya ; Tomita, Hideharu ; Kadokami, Toshiaki ; Imamura, Yoshihiro ; Ando, Shin-ichi ; Yamamoto, Koujirou (Maebashi, Japan)
14.05-14.10
224
Caspase-3, -8, and -9 activities in carbon tetrachloride, halothane, and sevoflurane-induced liver injury
Tanaka , Fumiaki ; Oishi , Chiyo ; Kagawa , Yuya ; Matsumoto , Natsuki ; Kato , Ryuji ; Ijiri , Yoshio ; Tanaka , Kazuhiko ; Hayashi , Tetsuya (Takatsuki, Japan)
14.10-14.15
221
Therapeutic drug monitoring of acetaminophen and its glucuronide in acetaminophen induced liver injury
Shimasaki, Yoriko ; Oishi, Chiyo ; Kagawa, Yuya ; Tanaka, Fumiaki ; Matsumoto, Natsuki ; Kato, Ryuji ; Ijiri, Yoshio ; Tanaka, Kazuhiko ; Hayashi, Tetsuya (Takatsuki, Japan)

13.20-14.05
Poster Session IX

Willen Burger Foyer

Erik Maarseveen (chair)

13.20-13.25
073
Population pharmacokinetics of amikacin in non-critical care pediatric Kuwaiti patients.
Dr Allanqawi , Yousef ; Buhamrah , Eman ; Demerdash , Zianab ; Al-Momen , Jawad (Kuwait, Kuwait)
13.25-13.30
092
Vancomycin clearance in neonates and infants with single ventricle: Influence of surgical procedure on the developmental trajectory within individuals
Shimamoto , Yuko ; Fukuda, Tsuyoshi ; Ichikawa, Hajime (Osaka, Japan)
13.30-13.35
157
Higher intestinal peptide transporter PEPT1 in human neonates and infants than in adults
Mooij, Miriam ; Koning, Barbara de ; Samsom, JN ; Kortleve-Lindenbergh, DJ ; Simons-Oosterhuis, Y ; Tibboel , Dick ; Wildt, SN de (Rotterdam, The Netherlands)
13.35-13.40
214
Optimizing busulfan exposure in pediatric hematopoietic cell transplantation using a weight-based dosing nomogram and therapeutic drug monitoring
PharmD Reij, Liesbeth van ; Maarseveen, E.M. van ; Bartelink, I.H. ; Egberts, A.C.G. ; Boelens, J.J. ; Rademaker, C.M.A. (Utrecht, The Netherlands)
13.40-13.45
226
Accidental digoxin overdose due to medication error in a child
Andrews , Louise ; Puiman , P.J. ; Sijs , I.H. van der ; Beynum , I.M. van (Rotterdam, The Netherlands)
13.45-13.50
240
TDM-VIGIL: A multicentre German-Austrian-Swiss pharmacovigilance study in child and adolescent psychiatry
Dr. Egberts, Karin ; Romanos, Marcel ; Plener, Paul ; Karwautz, Andreas ; Gerlach, Manfred (Würzburg, Germany)
13.50-13.55
350
LC-MS/MS method development – focus on bioanalysis of non-vitamin K oral antagonist anticoagulants (NOACs)
Blaich , Cornelia ; Müller , Carsten ; Wiesen , Martin (Cologone, Germany)
13.55-14.00
351
Drug Interactions: Update for Therapeutic Drug Monitoring (TDM) on Neonatal Intensive Care Units (NICU)
Rosen , Kai ; Wiesen , M.H.J. ; Nosseir , N. ; Blaich , C. ; Müller , C. (Cologone, Germany)

14.30-15.30
Anti-infective drugs III: ICU

Van Weelde Zaal

Veronique Stove/Jan Strojil (chairs)

14.30-14.42
212
The role of clinical pharmacological advices based on therapeutic drug monitoring in tailoring antimicrobial therapy in critically ill children
Prof. Baraldo , Massimo ; Cojutti , Piergiorgio ; Pea , Federico (Udine, Italy)
14.42-14.54
030
SIRS duration influences serum concentrations of vancomycin in sepsis patients
Ph.D. Chuma , Masayuki ; Makishima , Makoto ; Imai , Toru ; Tochikura , Naohiro ; Sakaue , Takako ; Kikuchi , Norikazu ; Kinoshita , Kousaku ; Kaburaki , Morio ; Yoshida , Yoshikazu (Tokyo, Japan)
14.54-15.06
233
MONITORING OF PIPERACILLIN AND MEROPENEM IN SEVERE SEPSIS
Professor Eliasson, Erik ; Giske, Christian ; Helldén, A ; Breuer, Olof ; Petersson, J (Stockholm, Sweden)
15.06-15.18
020
Contribution of population pharmacokinetics to dose optimization of ganciclovir/valganciclovir in solid organ transplant patients.
Padullés, Ariadna ; Colom, Helena ; Bestard, Oriol ; Melilli, Eduardo ; Sabé, Núria ; Rigo, Raul ; Niubó, Jordi ; Torras, Joan ; Lladó, Laura ; Manito, Nicolas ; Caldés, Anna ; Cruzado, Josep Maria ; Grinyó, Josep Maria ; Lloberas, Núria (Barcelona, Spain)
15.18-15.30
244
An assessment of the appropriateness of the first dosing regimen for vancomycin using therapeutic drug monitoring
Dr Yoon , Seonghae ; Park , Kyoung Ryun ; Jang , In-Jin ; Lee , Howard ; Yu , Kyung-Sang (Seoul, South-Korea)

14.30-15.30
Assays II

Van Beuningen Zaal

Kamisha Johnston-Davies/Brian Keevil (chairs)

14.30-14.42
250
Development and Validation of an UHPLC-HRAMS Creatinine Assay Using an Alternative Calibration Strategy
Breaud, Autumn ; Clarke, William (Baltimore, U.S.A.)
14.42-14.54
272
Evaluation of the Chromsystems MassTox assay for antifungal therapeutic drug monitoring (TDM) using LC-TMS.
Mr Chusney , Gary ; dr Cairns , Tom ; Chusney , Vivienne ; Freeman , Corinna ; James , Anthony ; Lee , Janet (London, United Kingdom)
14.54-15.06
349
Tacrolimus and cyclosporine comparison between Roche cobas 411 and Abbott Architect i2000.
Dr Vandenberghe, Hilde ; Yip, Paul ; Evert, Mark ; Romaschin, Alexander (Toronto, Canada)
15.06-15.18
108
Urinary mephedrone concentrations and cross-reactivity with an amfetamine Cloned Enzyme Donor Immunoassay (CEDIA)
Handley, Simon ; Belsey, SL ; Couchman, L ; Flanagan, RJ (London, United Kingdom)
15.18-15.30
111
Simultaneaous quantification of tamoxifen and metabolites in dry blood spot by liquid chromatograpy-tandem mass spectrometry
Tré-Hardy, Marie ; Capron, Arnaud ; Linden, Rafael ; Venzon Antunes, Marina ; Wallemacq, Pierre (Bruxelles, Belgium)

14.30-15.30
Other I

Plate/ Van Der Vorm Zaal

Teun van Gelder/Peter Zweipfenning (chairs)

14.30-14.42
113
Application of the AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry to Patients under Therapy with the Antipsychotics Clozapine, Olanzapine, and Risperidone in a Community Hospital in Germany
Renné, Daniel ; Bürgy, Martin ; Wieland, Eberhard ; Shipkova, Maria (Stuttgart, Germany)
14.42-14.54
294
PHARMACOKINETICS AND QT PROLONGATION OF SINGLE DOSE ESCITALOPRAM IN THE HEALTHY ELDERLY COMPARED WITH THE YOUNG
Chung, Hyewon ; Kim, AnHye ; Yoon, Seo Hyun ; Cho, Joo-Youn ; Yu, Kyung-Sang ; Chung, Jae-Yong (Seoul, South-Korea)
14.54-15.06
005
Instructions for clinical and biomarker monitoring in the Summary of Product Characteristics (SmPC) of psychotropic drugs: overview and applicability in clinical practice
MSc Nederlof, Mariette ; Stoker, Lennart ; Egberts, Toine ; Heerdink, Rob (Utrecht, The Netherlands)
15.06-15.18
055
Protective effect of atorvastatin and losartan either alone or in combination on changes in biochemical parameters related to ischemic reperfusion injury in an experimental animal cardiac model.
Prof EL Desoky , Ehab S. ; Fadil , Sabah A.M. ; Salem , Safaa Y. ; Hassan , Ayman K.M. ; Taha , Amira F. (Assiut, Egypt)
15.18-15.30
061
Statistical methodology for the untargeted screening of urine peptidomic biomarkers in kidney transplant recipients.
Dr. Woillard , Jean-Baptiste ; Sauvage , F.L. ; Essig , M. ; Marquet , Pierre (Limoges, France)

14.30-15.30
Pharmacogenetics II: Oncology

Jurriaanse Zaal

Laure Elens/Frederico Innocenti (chairs)

14.30-14.42
002
CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma
PharmD Diekstra, Meta ; Swen, Jesse ; Boven, Epie ; Castellano, Daniel ; Gelderblom, Hans ; Mathijssen , Ron ; Rodriguez-Antona, Cristina ; Garcia-Donas, Jesus ; Rini, Brian ; Guchelaar, Henk-Jan (Leiden, The Netherlands)
14.42-14.54
044
Impact of genetic polymorphisms of P-glycoprotein (ABCB1) on intracellular accumulation and therapeutic activity of tyrosine kinase inhibitors.
Dessilly, Geraldine ; Elens, Laure ; Demoulin, Jean-Baptiste ; Haufroid, Vincent (Brussels, Belgium)
14.54-15.06
138
Lethal toxicity of 5-fluorouracil in the era of personalized therapy: discovery of a novel mutation disrupting the dihydropyrimidine deshydrogenase activity.
THOMAS, Fabienne ; Hennebelle, Isabelle ; Marsili, Sabrina ; Dhelens, Carole ; Garnier-Tixidre, Claire ; Bonadona, Agnes ; PENEL, Nicolas ; Goncalves, Anthony ; Delord, Jean Pierre ; Toulas, Christine ; Chatelut, Etienne (Toulouse cedex 9, France)
15.06-15.18
213
Polymorphisms in MIR27A associated with early-onset toxicity in fluoropyrimidine-based chemotherapy
Amstutz, Ursula ; Offer, S.M. ; Sistonen, J. ; Joerger, M. ; Diasio, R.B. ; Largiadèr, C.R. (Bern, Switzerland)
15.18-15.30
091
An evaluation of Dutch pharmacists’ knowledge, experience, and attitudes towards pharmacogenetic testing: results of a nationwide survey
Drs. Bank, Paul ; Swen, Jesse ; Guchelaar, Henk-Jan (Leiden, The Netherlands)

14.30-15.30
Pharmacometrics II

Mees Zaal

Ron Mathot/Franck Saint-Marcoux (chairs)

14.30-14.42
256
Nonparametric population pharmacokinetic modeling of mycophenolic acid in hematopoietic Stem Cell transplant patients.
Lebreton , Vincent ; Saint-Marcoux , Franck ; Turlure , Pascal ; Nolain , Patrick ; Girault , Stéphane ; Marquet , Pierre ; Woillard , Jean-Baptiste (Presenting author) (Limoges, France)
14.42-14.54
270
Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients.
Moes , Dirk Jan ; Bent , S.A.S. van der ; Swen , J.J. ; Straaten , T. van der ; Inderson , A. ; Olofsen , E. ; Verspaget , H.W. ; Guchelaar , H.J. ; Hartigh , J. den ; Hoek , B. van (Leiden, The Netherlands)
14.54-15.06
274
Prediction of Maximum Tolerated Dose (MTD) for Hydroxyurea Treatment using Bayesian Adaptive Control in Children with Sickle Cell Anemia
Dong , Min ; Mcgann , Patrick T. ; Mizuno , Tomoyuki ; Ware , Russell E. ; Vinks , Alexander A. (Cincinnati, U.S.A.)
15.06-15.18
323
A new CYP3A5*3 and CYP3A4*22 cluster influencing tacrolimus target dose-concentrations: a population approach.
Andreu , Franc ; Colom , Helena ; Elens , Laure ; Schaik , Ron van ; Gelder , Teun van ; Hesselink , Dennis ; Bestard , Oriol ; Padullés , Ariadna ; Torras , Joan ; Cruzado , Jm ; Grinyó , Jm ; Lloberas , Núria (Barcelona, Spain)
15.18-15.30
267
Identifying risk factors for everolimus serious side effects and discontinuation in renal transplant recipients on everolimus and prednisolone dual therapy.
Moes , Dirk Jan ; Jönsson , S. ; Hartigh , J. den ; Straaten , T. van der ; Homan van der Heide , J.J. ; Sanders , J.S. ; Bemelman , F.J. ; Guchelaar , H.J. ; Karlsson , M.O. ; Fijter , J.W. de (Leiden, The Netherlands)

14.35-15.30
Poster Session X

Willen Burger Foyer

Daan Touw (chair)

14.35-14.40
099
HONEY-PROPOLIS HEPATOPROTECTIVE EFFECT ON ALCOHOL-INDUCED HEPATOCYTOTOXICITY IN VITRO IN NORMAL HUMAN HEPATOCYTES
Prof. Neuman , Manuela ; Nanau , Radu (Toronto, Canada)
14.40-14.45
101
Hepatic Sinusoidal Obstruction Syndrome induced by Pyrrolizidine Alkaloids
Prof. Neuman , Manuela ; Prof. Steenkamp , Vanessa ; Dr. Winkler , Robert (Toronto, Canada)
14.45-14.50
102
Alcohol-enhance hepatocytotoxicity Profile of Pyrrolizidine Alkaloid-Containing Medicinal Plants in vitro Normal Human Hepatocytes
Prof. Neuman , Manuela ; Prof. Steenkamp , Vanessa (Toronto, Canada)
14.50-14.55
260
LCMSMS quantitative analysis of Anti-Depressants and Tricyclic Anti-Depressants in urine, oral fluids and serum and evaluation and comparison of sample preparation techniques
Dr. Doyle , Rory ; ph.d Frick , Lauren ; ph.d Cote , Linda ; ph.d Szczesniewski , Andre ; ph.d Cichelli , Julie (Presenting author) (Hockessin, U.S.A.)
14.55-15.00
149
Vitreous humor as an alternative matrix for the analysis of alcohol intoxication in post mortem forensic toxicology
MD Zago , Silvia ; Colatutto , Antonio ; Baraldo , Massimo ; Curcio , Francesco (Udine, Italy)
15.00-15.05
155
Environmental and biological monitoring of occupational formaldehyde exposure resulting from the use of products for hair straightening
MSc Peteffi , Giovana ; Antunes , Marina ; Caroline , Carrer ; Valandro , Eduarda ; Santos , Sílvia ; Glaeser , Jéssica ; Mattos , Larissa ; Da Silva , Luciano ; Linden , Rafael (Presenting author) (Novo Hamburgo, Brazil)
15.05-15.10
168
Investigating a case of suspected poisoning with the synthetic cannabinoid AB-CHMINACA.
Dr. O’Halloran , Sean ; O’Halloran , Sean (Nedlands, Australia)
15.10-15.15
184
ETHANOL SCREENING FOR EMERGENCY DEPARTMENT: THE ROLE OF THE REFERENCE LABORATORY
dr Bianchi , Vincenza ; Dr. Callegari , Tiziana ; Dr. Casalecchi , Maria ; Dr. Mirone , Gabriella ; Guaschino , Roberto (Alessandria, Italy)
15.15-15.20
204
Determination of dapsone and monoacetyldapsone using HPLC/UV
Dr Schneider , Serge ; Sonemann , Anja ; Dr. Faik , Nawfal (Dudelange, Luxembourg)
15.20-15.25
208
NEONATAL SEROTONIN SYNDROME AFTER IN UTERO EXPOSURE TO SERTRALINE AND PERPHENAZINE
M.D. ELEFTHERIOU, GEORGIOS ; BUTERA, RAFFAELLA ; GALLO, MARIAPINA ; BACIS, GIUSEPPE ; CONTESSA, GIOIA ; FARAONI, LORELLA (BERGAMO, Italy)

14.35-15.30
Poster Session XI

Willen Burger Foyer

Tomasz Pawinski (chair)

14.35-14.40
119
A UPLC-MS/MS Clinical Research Method for the Analysis of Plasma Mycophenolic Acid
Hammond Gareth, MRS WILLS, MICHELLE (WILMSLOW, United Kingdom)
14.40-14.45
125
Performance evaluation of a new automated tacrolimus assay on Dimension® systems
Brugnolo, Laura ; Artusi, C ; Marinova, M ; Varagnolo, MC ; Zaninotto, M ; Plebani, M (Padova, Italy)
14.45-14.50
127
Influence of Clinical and Genetic Factors on Everolimus Maintenance Therapy in Heart Transplant Patients
Lesche, Dorothea ; Sigurdardottir, Vilborg ; Setoud, Raschid ; Englberger, Lars ; Fiedler, Georg Martin ; Largiadèr, Carlo ; Mohacsi, Paul ; Sistonen, Johanna (Bern, Switzerlan
14.55-15.00
172
An External Evaluation of Published Tacrolimus Population Pharmacokinetic Models in Adult Renal Transplant Recipients
Zhao , Chenyan ; Mao , Junjun ; Jiao , Zheng (Presenting author) (Shanghai, China)
15.00-15.05
175
EVEROLIMUS AND VORICONAZOLE INTERACTION IN LUNG TRANSPLANT PATIENTS
Outeda, Maria ; Salvador, P ; Elberdín, L ; Martín, I (A Coruña, Spain)
15.05-15.10
181
PHARMACOKINETIC INTERACTION BETWEEN TACROLIMUS AND VORICONAZOLE IN LUNG TRANSPLANT PATIENTS
Salvador, Pilar ; Outeda, M ; Elberdín, L ; Pedreira, I ; Martín, I (A Coruña, Spain)
15.10-15.15
183
INFLUENCE OF CYP3A4, CYP3A5 AND MDR1-C3435T GENETIC POLYMORPHISMS ON ITRACONAZOLE-TACROLIMUS INTERACTION IN ADULT RENAL TRANSPLANT PATIENTS
Salvador, Pilar ; Outeda, M ; Pedreira, I ; Martín, I (A Coruña, Spain)
15.15-15.20
117
Performance of a phosphoflow assay to determine phosphorylation of S6 ribosomal protein as a read out for mTOR inhibition
M.Sc. Abdel-Kahaar, Emaad ; Kabakchiev, Mariana ; Hartmann, Bertram ; Wieland, Eberhard ; Shipkova , Maria (Stuttgart, Germany)
15.20-15.25
209
A novel UPLC-MS/MS method for clinical research of methotrexate pharmacokinetics
Balloch, Stephen ; Hammond, G ; Molinelli, Dr A R ; Chaloner, C ; Tetlow, L (Wilmslow, United Kingdom)
15.25-15.30
215
Closer to the site of action; everolimus concentrations in peripheral blood mononuclear cells correlate well with whole blood concentrations using a nonparametric population model
Robertsen, Ida ; Vethe, Nils Tore ; Midtvedt, Karsten ; Falck, Pål ; Christensen, Hege ; Neely, Michael ; Åsberg, Anders (Oslo, Norway)

14.35-15.30
Poster Session XII

Willen Burger Foyer

Alwin Huitema (chair)

14.35-14.40
015
“To Determine If The Concentration Of Phenobarbitone In Serum Can Be Accurately Predicted From That Measured In Dried Blood Spot Specimens”
Dr Mathew , Aswathy ; Fleming , Denise ; Prabhakar , A.T.P. ; Jeyaseelan , Visalakshi ; Ernest , Kalpana ; Alexander , Mathew (Vellore, India)
14.40-14.45
494
Development and validation of a high performance liquid chromatography-tandem mass spectrometric method for the determination of imatinib in dried blood spots
Prof. Antunes , Marina ; Raymundo , Suziane ; Vieira , Natália ; Reginato , Fabíola ; Fogliatto , Laura ; Wagner , Sandrine comparsi ; Capra , Marcelo ; Linden , Rafael (Novo Hamburgo, Brazil)
14.45-14.50
109
Stratum corneum uptake reflects the area-corrected topical dose of hydrocortisone
Dr Delgado Charro, Begoña ; Paterson, Daniel ; Cordery, Sarah (Bath, United Kingdom)
14.50-14.55
114
Application of Dried Blood Spots combined with ultra-high performance liquid chromatography-mass spectrometry for the identification and quantification of the antipsychotics risperidone, aripiprazole, pipamperone and their major metabolites
Tron , Camille J.M. ; Wijma , Rixt A. ; Nagel , Bart C.H. van der ; Dierckx , Bram ; Verhulst , Frank C. ; Dieleman , Gwen C. ; Touw , Daan J. ; Gelder , Teun van ; Koch , Birgit C.P. (Rotterdam, The Netherlands)
14.55-15.00
313
Design of an LC-MS/MS method for measuring concentrations of Cyclosporine A and Tacrolimus from dried blood spots suitable for automation
Ph D student Linder, Camilla (HUDDINGE, Sweden)
15.00-15.05
021
Co-administration of proton pump inhibitor decreases plasma concentration of erlotinib in patients with non-small cell lung cancer
Ogami, Masahiro ; Suzuki, Yoshiharu ; Naito, Kanako ; Yamada, Motoko ; Kaburagi, Takayuki ; Uchiumi, Keiko ; Yamada, Yutaka ; Takei, Keiji ; Homma, Masato (Kasama, Japan)
15.05-15.10
069
Separation and quantitative determination of the BCR-Abl tyrosine kinase inhibitors in human plasma by high-performance liquid chromatography with ultraviolet detection
Yokokawa, Akitomo ; Ono, Risa ; Hosoda, Kaori ; Ishii, Kazuo ; Furuta, Takashi ; Shibasaki-Hirano, Hiromi (Tokyo, Japan)
15.10-15.15
118
Determination of the separation method of aminoalkanol derivatives of dicarboximides as a potential anticancer drugs by Capillary Electrophoresis.
dr Grodner, Błażej ; Krawiecka, Mariola ; Łukaszkiewicz, Jacek (Warsaw, Poland)
15.15-15.20
177
Increase in steady-state plasma concentrations of 5-fluorouracil (5-FU) via the suppression of dihydropyrimidine dehydrogenase activity by a bolus injection of 5-FU in advance
Dr. Kobuchi , Shinji ; Dr. Ito , Yukako ; Prof. Tamura , Takao ; Prof. Sakaeda , Toshiyuki (Kyoto, Japan)
15.20-15.25
070
Clinical pharmacokinetics of 3-weekly docetaxel in cancer patients
Shibasaki-Hirano, Hiromi ; Ohomori, Yuhei ; Fukawa, Noriyuki ; Yokokawa, Akitomo ; Nagashima, Fumio ; Kasuga, Akiyoshi ; Naruge, Daisuke ; Kitamura, Hiroshi ; Okano, Naohiro ; Furuse, Junji ; Furuta, Takashi (Tokyo, Japan)
15.25-15.30
141
UTILITY OF URACIL AND 5-6 DIHYDROURACIL CONCETRATIONS AND URACIL: 5-6 DIHYDROURACIL RATIO IN PREDICTING 5-FLUOROURACIL (5-FU) TOXICITY
PhD Egues , Amaia ; PhD Aldaz , Azucena (Presenting author) (Pamplona, Spain)

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