Concurrent Abstracts and Posters Monday October 12

13.15-14.15
Clinical Toxicology I: Screening for intoxications

Jurriaanse Zaal

William Clarke/Eric Franssen (chairs)

13.15-13.27
064
Comprehensive Toxicological Analysis of Clinical Urine Samples with the ToxtyperTM Compared to a Standard GC/EI-MS-FullScan Method
Lohrmann, Stefanie; Boettcher, Michael (Presenting author) (Dessau, Germany)
13.27-13.39
041
Dried urine spots an alternative for drug testing? Comparison of detectability using an LC-MSn screening approach after urine precipitation
Michely, Julian A.; Meyer, Markus; Maurer, Hans (Homburg, Germany)
13.39-13.51
346
Optimization of data analysis parameters for clinical toxicology testing using high resolution mass spectrometry
Dr. Lynch, Kara ; Colby, Jennifer ; Thoren, Katie (San Francisco, United States of America)
13.51-14.03
075
Screening for Targeted and Non-targeted New Psychoactive Substances and Drugs of Abuse by Ultra-High Performance Liquid Chromatography- Time-of-Flight Mass Spectrometry
Dr. Pelander, Anna ; Sundström, M ; Ojanperä, I (University of Helsinki, Finland)
14.03-14.15
341
Broad Spectrum Urine Drug Screening: the challenges of assessing qualitative cut-off performance characteristics in an LCMSMS System
Dr. Beach, Lori ; Colantonio, David (Presenting author) (Hamilton, Canada)

13.15-14.15
Anti-infective drugs I: HIV

Van Weelde Zaal

David Burger/Dario Cattaneo (chairs)

13.15-13.27
057
Metabolic and kidney disorders correlate with high atazanavir concentrations in HIV-infected patients: is it time to revise atazanavir dosages?
Dario , Cattaneo ; Meraviglia , P. ; Minisci , D. ; Ferraris , L. ; Riva , A. ; Landonio , S. ; Cozzi , V. ; Charbe , N. ; Molinari , L. ; Rizzardini , G. ; Clementi , E. ; Galli , M. ; Gervasoni , C. (Milan, Italy)
13.27-13.39
066
Factors affecting bone diseases development in HIV patients on tenofovir-based therapy
Dario , Cattaneo ; Minisci , D. ; Resnati , C. ; Baldelli , S. ; Meraviglia , P. ; Galli , M. ; Rizzardini , G. ; Clementi , E. ; Gervasoni , C. (Milan, Italy)
13.39-13.51
249
Development and Implementation of a Rapid HPLC-HRAMS Screening Method for Detection of Twenty Antiretroviral (ARV) Compounds in Human Serum
Breaud, Autumn ; Clarke, William (Baltimore, U.S.A.)
13.51-14.03
237
Darunavir unbound fraction: association with viral load in HIV patients.
Metsu, David ; Gandia, GP ; Delobel, DP ; Seraissol, SP ; Saint-Marcoux, SMF ; Marquet, MP ; Izopet, IJ ; Chatelut, CE ; Woillard, WJB (Toulouse, France)
14.03-14.15
128
Rilpivirine concentrations and effects on QTc interval in patients treated with boceprevir for acute hepatitis C virus infections
dr. Winter, Brenda de ; Hullegie, S.J. ; Posthouwer, D. ; Koopmans, P.P. ; Claassen, M.A.A. ; Rijnders, B.J.A. (Rotterdam, The Netherlands)

13.15-14.15
Immunosuppressive drugs I

Ruys/Van Rijckevorsel Zaal

Merce Brunet/Dennis Hesselink (chairs)

13.15-13.27
043
Population pharmacokinetics and exposure-renal toxicity study of cyclosporine A during the first weeks after allogeneic hematopoietic stem cell transplantation
Nolain , Patrick ; Woillard , Jean-Baptiste (Presenting author); Turlure , Pascal ; Marquet , Pierre ; Saint-Marcoux , Franck (Limoges, France)
13.27-13.39
265
Polymorphisms in genes of the calcineurin response pathway and risk of Post Transplant Lymphoproliferative disease: a case-control study
Dr. Stojanova, Jana ; Caillard, Sophie ; Pouché, Lucie ; Woillard, Jean-Baptiste ; Picard, Nicolas ; Marquet, Pierre (Santiago, Chile)
13.39-13.51
257
The different regulation of Tregs and Th17/Th1 cells by Sirolimus-based Regimen might be Dependent on STAT-signaling in Renal Transplant Recipients
Lanlan , Wang ; Dr. Li , Yi (Presenting author); Dr. Bai , Yangjuan ; Dr. Zhang , Junlong ; Dr. Shi , Yunying (Chengdu, China)
13.51-14.03
348
Immunoregulation of Tacrolimus on BTLA expression on T lymphocyte subsets in allo-liver recipients
Cai , Bei ; Zhang , Junlong ; Bai , Yangjuan ; Li , Yi ; Huang , Zhuochun ; Liao , Yun ; Wang , Lanlan (Chengdu, China)
14.03-14.15
028
Use of Graft Derived, Cell-free DNA Percentages (GcfDNA) to Monitor Effects of Immunosuppressive Drug (ISD) Combinations in Liver Transplant (LTx) Patients Including During ISD Switches
Schmitz , Jessica ; Beck , Julia ; Schütz , Ekkehard (Presenting author); Reinhard , Lena ; Kanzow , Philipp ; Walson , Philipp D. ; Kollmar , Otto ; Oellerich , Michael (Göttingen, Germany)

13.15-14.15
New Sampling drugs I: Dried blood spots

Van Beuningen Zaal

Birgit Koch/Christoph Stove (chairs)

13.15-13.27
173
Dried blood spot (DBS) techniques for the monitoring of ambrisentan, bosentan, sildenafil, and tadalafil in patients with pulmonary arterial hypertension
Enderle, Yeliz ; Witt, Lukas ; Hohmann, Nicolas ; Wilkens, Heinrike ; Friedrich, Jörg ; Grünig, Ekkehard ; Haefeli, Walter ; Burhenne, Jürgen (Heidelberg, Germany)
13.27-13.39
277
Dried Blood Spot Multiplex Immunosuppressant Assay on Pre-impregnated Cards with Deuterated Internal Standards by LC-MS/MS
Dr Pattanaik , Smita ; Dr Ritchie , James C (Chandigarh, India)
13.39-13.51
035
Could differences in potassium based hematocrit explain deviations between dried blood spot and plasma analysis of amitriptyline, nortriptyline, clomipramine, desmethyl-clomipramine, venlafaxine, and O-desmethylvenlafaxine in patient samples?
Berm, Elizabeth ; Odigie, B ; Wilffert, B ; Touw, D.J. ; Maring, J.G. (Groningen, The Netherlands)
13.51-14.03
182
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study
Kesel , Pieter de ; Lambert , Willy ; Stove , Christophe (Ghent, Belgium)
14.03-14.15
236
An innovative method to estimate the hematocrit of dried blood spots.
Capiau, Sara ; Wilk, LS ; Aalders, MCG ; Stove, CP (Ghent, Belgium)

13.15-14.15
Pediatrics I

Schadee Zaal

Saskia de Wildt/Sander Vinks (chairs)

13.15-13.27
159
Everolimus pharmacokinetics in pediatric patients with subependymal giant-cell astrocytomas associated with tuberous sclerosis complex
Mizuno , Tomoyuki ; Fukuda , Tsuyoshi ; Krueger , Darcy ; Vinks , Alexander (Cincinnati, U.S.A.)
13.27-13.39
008
VANCOMYCIN THERAPY IN CRITICALLY ILL CHILDREN: An urgent plea for pharmacokinetic-pharmacodynamic research integrating protein binding
PharmD Cock , Pieter de ; Desmet , Sarah ; Louise , Coene ; Jaeger , Annick de ; Dhont , Evelyn ; Stove , Veronique ; Robays , Hugo ; de Paepe , Peter (Ghent, Belgium)
13.39-13.51
087
A Novel Combination Approach for Age-Appropriate Clearance Estimation in Neonates and Infants: Use of Therapeutic Drug Monitoring Data to Explore the Developmental Trajectory
Emoto , Chie ; Fukuda , Tsuyoshi ; Mizuno , Tomoyuki ; Schniedewind , Bjoern ; Johnson , Trevor ; Christians , Uwe ; Adams , Denise ; Vinks , Alexander (Cincinnati, United States of America)
13.51-14.03
314
Development of an optimal dosing regimen for oral methadone treatment in neonatal abstinence syndrome: Application of population pharmacokinetic modeling and simulation
Mizuno , Tomoyuki ; Wiles , Jason ; Isemann , Barbara ; Tabangin , Meredith ; Ward , Laura ; Akinbi , Henry ; Fukuda , Tsuyoshi ; Vinks , Alexander (Cincinnati, U.S.A.)
14.03-14.15
145
Busulfan Dosing and Veno-Occlusive Disease Following Allogeneic Hematopoietic Stem Cell Transplantation: A Pediatric Case Series
Kaur, Dominder ; Nageswara Rao, Amulya ; Rodriguez, Vilmarie ; Warad, Deepti ; Gourde, Julia ; Khan, Shakila ; Langman, Loralie (Presenting author) (Rochester, United States of America)

13.20-14.05
Poster Session I

Willen Burger Foyer

Veronique Stove (chair)

13.20-13.25
187
FLUCONAZOLE EXPOSURE IN PATIENTS ON THE ICU WITH INVASIVE CANDIDIASIS: A PROSPECTIVE STUDY
Bsc. Boonstra, Jasper ; Zijlstra, JG ; Arends, JP ; Kosterink, JGW ; Werf van de, TS ; Touw, DJ ; Alffenaar, JWC (Groningen, The Netherlands)
13.25-13.30
273
Pegasys, ribavirin or leucogen can induce anti-RR antibody for hepatitis C patient?
Wu, Yongkang ; Luo, L ; Huang, Z ; Cai, B ; Tan, C ; Wang*, L (Presenting author) (Chengdu, China)
13.30-13.35
305
Oral ribavirin for (lung transplanted) patients with a paramyxovirus infection: a comparison of ribavirin plasma levels with the IC50
Burg , Marleen van der ; Nawar , N.A. ; Verschuuren , E.A.M. ; Meijdam , B.T. ; Alffenaar , Jan Willem ; Riezebos-Brilman , A. (Groningen, The Netherlands)
13.35-13.40
017
The importance of therapeutic drug monitoring of antimicrobials in ICU patients
Luo, Xuemei (Nanjing, China)
13.40-13.45
024
Quantification of the antiviral drugs dolutegravir, elvitegravir, rilpivirine and daclatasvir in human plasma using LC-MS/MS
Dr. Mueller, Daniel ; Kuehnis, Rita (Zurich, Switzerland)
13.45-13.50
052
First experience with proficiency testing for therapeutic drug monitoring of rilpivirine in The International Quality Control Program for Measurement of Antiretroviral Drugs in Serum
Prof Burger, David ; Robijns , Karen ; Aarnoutse , Rob ; Touw, Daan (Nijmegen, The Netherlands)
13.50-13.55
060
Changes in the pharmacokinetics of teicoplanin in patients with hyperglycemic hypoalbuminemia: impact of albumin glycosylation on the binding of teicoplanin to albumin
Enokiya, Tomoyuki ; Muraki, Yuichi ; Iwamoto, Takuya ; Okuda, Masahiro (Tsu, Japan)
13.55-14.00
229
Therapeutic drug monitoring of daptomycin in severely-ill patients
Prof. Di Paolo, Antonello ; Polillo, Marialuisa ; Tascini, Carlo ; Ciofi, Laura ; Sarli, Valentina ; Menichetti, Francesco ; Danesi, Romano (Pisa, Italy)
14.00-14.05
309
An alternative method for quantification of tigecycline, a reserve antibiotic glycylcycline, by means of liquid chromatography with electrochemical detection.
Dr. Ameln-Mayerhofer, Andreas von ; Loeffler, Matthias (Sindelfingen, Germany)

13.20-13.55
Poster Session II

Willen Burger Foyer

Vincent Haufroid (chair)

13.20-13.25
093
Genotype-Phenotype Relationship of Inosine Triphosphate Pyrophosphatase (ITPA) among normal and abnormal Thiopurine S-Methyltransferase (TPMT) activity samples.
PhD Johnson-Davis , Kamisha L. ; PhD Melis , Roberta ; PhD Mcmillin , Gwendolyn (Salt Lake City, United States of America)
13.25-13.30
163
CYP2B6*2 and CYP2B6*9 allele significantly elevate nevirapine plasma concentrations in Malaysian HIV patients.
Mustafa , Suzana ; Wan Yusuf , Wan Nazirah ; Tan , Soo Choon ; Hassan , Norul Badriah (Kubang Kerian Kelantan, Malaysia)
13.30-13.35
193
Distribution of allelic and genotypic frequencies of N-Acetyltransferase-2 (NAT2) and cytochrome P450 2E1 (CYP2E1) variants in an Tunisian tuberculosis population
Ben Fredj, Nadia ; GAM, Ryhem ; KERKENI, Emna ; CHEDLY, Zohra ; CHAABANE, Amel ; BOUGHATTAS, Naceur ; AOUAM, Karim (Presenting author) (Monastir, Tunisia)
13.35-13.40
289
Multiplex targeted long amplicon sequencing method for Cyp2d6 genotyping using the PacBio RSII
Dr. Swen , Jesse ; Buermans , Henk ; Straaten , Tahar van der ; Vossen , Rolf ; Anvar , Yahya ; Dunnen , Johan den (Leiden, The Netherlands)
13.40-13.45
290
Relative influence of donor and recipient CYP3A5*3 variant genotype in PK-Tacrolimus of liver transplant recipients
Buendia , Jefferson Antonio ; Riva , N. ; Halac , E. ; Bosaleh , A. ; Caceres , P. ; Imventarza , O. ; Garcia de Davila , M.T. ; Schaiquevich , P. ; Bramuglia , G.F. (Medellin, Colombia)
13.45-13.50
009
Association analysis of single nucleotide polymorphisms related to response and toxicity of sunitinib in patients with matestatic renal cell carcinoma: a multicenter study.
LIU, XIAOYAN ; Diekstra, M.H.M ; Swen, J.J ; Boven, E ; Castellano, D ; Gelderblom, H ; Mathijssen, R.H.J ; Rodríguez-Antona, C ; García-Donas, J ; Rini, B.I. ; Guchelaar, HJ (Leiden, The Netherlands)
13.50-13.55
038
Preliminary results on the pharmacoepigenetics of calcineurin inhibitors using an in-vitro model: pitfalls and perspectives
Resident POUCHE, Lucie ; Lebreton, Vincent ; Gonzalez, Julien ; Marquet, Pierre ; Picard, Nicolas (LIMOGES, France)

13.20-14.15
Poster Session III

Willen Burger Foyer

Milan Grundmann (chair)

13.20-13.25
025
A case report of clonazepam abuse – utilization of therapeutic drug monitoring during withdrawal period
MD, PhD Kacirova , Ivana ; md, phd Grundmann , Milan ; md Silhan , Petr ; dr., phd Brozmanova , Hana (Ostrava, Czech Republic)
13.25-13.30
014
Effect of changes in legal sales status and therapeutic recommendations of domperidone and metoclopramide on the number of overdoses
Mulder-Spijkerboer , Henneke N. ; Riel , A.J.H.P. van ; Vries , I. de (Utrecht, The Netherlands)
13.35-13.40
107
Urinary benzoylecgonine and levamisole concentrations in samples sent for clinical drug screening: Failure to detect aminorex
Handley, Simon ; Belsey, SL ; Couchman, L ; Flanagan, RJ (London, United Kingdom)
13.40-13.45
120
An automated multi-bioanalysis method, determination of haloperidol, zuclopentixol, risperidone, 9-hydroxyrisperidone, sertraline and its metabolite desmethylsertraline in human plasma by LC-MS/MS
Rönquist, Yuko ; Gustafsson, L ; Gambell Barroso, M ; Pohanka, A (Stockholm, Sweden)
13.45-13.50
174
The screening of skin carotenoids concentrations (SCC) in patients with cardiovascular diseases and Diabetes Melitus: An association assessment in single study.
Associate Prof. Tewthanom , Karunrat ; Dr. Musichai , Chatdanai ; Usayaporn , Thunyanee (Nakhonpathom, Thailand)
13.50-13.55
180
Establishment of simultaneous quantification of estrone and 16a-hydroxyestrone in human urine using ultra performance liquid chromatography-tandem mass spectrometry.
Kaneko, Tetsuya ; Suzuki, Yosuke ; Fujioka, Takashi ; Tanaka, Ryota ; Oyama, Nobuhiro ; Sato, Yuhki ; Itoh, Hiroki (Oita, Japan)
13.55-14.00
219
C-reactive protein and serum concentrations of the antipsychotic drugs clozapine, quetiapine and risperidone – is there a relationship?
Prof. Dr. Hiemke , Christoph ; Hefner , Gudrun ; Shams , Mohamed ; Unterecker , Stefan ; Falter , Tanja (Mainz, Germany)
14.00-14.05
230
USE OF PK/PD/PGx SOFTWARE FOR MODELING, TDM AND CLINICAL PRACTICE TO DEMONSTRATE THE TOLBUTAMIDE STIMULATION OF INSULIN RELEASE.
Dousa , Jiri ; Prell , Jan ; Potucek , Jiri ; Punt , Nieko (Prague, Czech Republic)
14.10-14.15
242
Evaluation of a dose-related reference range of buprenorphine in opiate substitution treatment
Laib, Anne Kathrin ; Beck, Olof ; Böttcher, Michael ; Jellinek, Christian ; Hiemke, Christoph ; Kakko, Johan ; Havemann-Reinecke, Ursula (Mainz, Germany)

14.30-15.30
Anti-infective drugs II: Anti Mycotics and Aminoglycosides

Van Weelde Zaal

Birgit Koch/Daan Touw (chairs)

14.30-14.42
134
Comparative Pharmacokinetics of Echinocandins in Intensive Care Unit patients
Lempers, Vincent (Nijmegen, The Netherlands)
14.42-14.54
304
LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY METHOD FOR SIMULTANEOUS QUANTIFICATION OF ECHINOCANDINS IN HUMAN PLASMA: APPLICATION TO PEDIATRIC PATIENTS
De Gregori , Simona, ; Ventura , Marianna ; Michelini , Roberta ; Comoli , Patrizia ; Rubert , Laura ; Zecca , Marco ; Molinaro , Mariadelfina (Presenting author) (Pavia, Italy)
14.54-15.06
269
Evaluation of the plasma unbound fraction of Voriconazole
Florent , Aurélie ; Seraissol , S.P. ; Metsu , M.D. (Presenting author); Chatelut , C.E. ; Gandia , G.P. (Toulouse, France)
15.06-15.18
098
Antimicrobial underexposure in intensive care patients with “normal” renal function
Dr Sandaradura, Indy ; Norris , Ross ; Jones, G ; Rudham, S ; Day, R ; Marriott, D (Darlinghurst, Australia)
15.18-15.30
332
Risk of gentamicin-induced nephrotoxicity in the context of new recommendations for its therapeutic drug monitoring: a 4-year retrospective study.
Lebreton , Vincent ; Monchaud , Caroline ; Saint-Marcoux , Franck ; Marquet , Pierre ; Woillard , Jean-Baptiste (Presenting author) (Limoges, France)

14.30-15.30
Assays I

Van Beuningen Zaal

Ron Mathot (chair)

14.30-14.42
083
Reagentless Vancomycin sensor using molecularly imprinted polymer including redox group
Prof. Yoshimi, Yasuo (Tokyo, Japan)
14.42-14.54
132
Toxicology screening method for human brain samples
Dr. Jiang, Hongfeng ; Dwork, Andrew ; Rosoklija, Gorazd ; Cooper, Thomas ; Cremers, Serge (Presenting author) (New York City, United States of America)
14.54-15.06
148
Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for the concomitant quantification of dabigatran, rivaroxaban and apixaban in human plasma
Dario , Cattaneo ; Baldelli , S. (Presenting author); Perrone , V. ; Clementi , E. (Milan, Italy)
15.06-15.18
205
WITHIN-INDIVIDUAL BIOLOGICAL VARIATION DATA FOR THERAPEUTIC DRUG MEASUREMENTS
A/Prof Jones, Graham (Darlinghurst, Australia)
15.18-15.30
206
CD86-expression on monocytes as a tool for therapeutic drug monitoring of belatacept
MD Graav, Gretchen de ; Hesselink, Dennis ; Verschoor, Wenda ; Dieterich, Marjolein ; Gelder, Teun van ; Weimar, Willem ; Baan, Carla (Rotterdam, The Netherlands)

14.30-15.30
Immunosuppressive drugs II

Ruys/Van Rijckevorsel Zaal

Pierre Marquet/Maria Shipkova (chairs)

14.30-14.42
007
Polymorphisms of CYP3A5/MDR-1 and Posttransplantation Diabetes Mellitus (PTDM)
Chen, Jie ; An, yunfei ; Li, lixin ; Li, yi ; Liao, yun ; Wang, lanlan (Chengdu, China)
14.42-14.54
110
SINGLE CELL PHOSPHO-PROTEIN ANALYSIS DEMONSTRATES THAT IMMUNOSUPPRESSIVE DRUGS INHIBIT MAPK AND MTOR SIGNALING MOLECULES IN PRIMARY MONOCYTES AFTER TRANSPLANTATION
Kannegieter , Nynke ; Hesselink , Dennis ; Kraaijeveld , Rens ; Graav , Gretchen de ; Betjes , Michiel ; Weimar , Willem ; Baan , Carla (Rotterdam, The Netherlands)
14.54-15.06
116
Analytical validation and cross validation of a commercially available NFAT-regulated gene expression assay
M.Sc. Abdel-Kahaar, Emaad ; Rieger, Hannah ; Sommerer, Claudia ; Giese, Thomas ; Shipkova , Maria ; Wieland, Eberhard (Stuttgart, Germany)
15.06-15.18
185
Is it possible to predict the rejection risk after kidney transplantation with a pre-transplant immunosuppressant sensitivity assay?
Vethe , Nils Tore ; Klaasen , Rolf A. ; Hole , Kristine ; Bremer , Sara ; Berg , Christine ; Skauby , Morten ; Midtvedt , Karsten ; Line , Pål-Dag ; Bergan , Stein (Oslo, Norway)
15.18-15.30
258
The remission of renal injury in tacrolimus to sirolimus conversion renal transplant recipients is dependent on the inhibiton of Cytokine- Chemokines signaling
Lanlan , Wang ; Dr. Li , Yi (Presenting author); Dr. Shi , Yunying ; Dr. Bai , Yangjuan ; Dr. Zhang , Junlong (Chengdu, China)

14.30-15.30
Pharmacogenetics I: Miscellaneous

Jurriaanse Zaal

Nicolas Picard/Ron van Schaik (chairs)

14.30-14.42
001
Aberrant CYP2D6 metabolizer phenotypes do not show increased frequency in patients undergoing ECT after antidepressant therapy
Hooman , Mirzakhani ; Dormolen , Juliët van ; Weide , Karen van der ; Guchelaar , Henk Jan ; Noorden , Martijn S. van ; Swen , Jesse (Presenting author) (Leiden, The Netherlands)
14.42-14.54
123
Quantative Effect of CYP2C19 and CYP2C9 Genotype on Concentration Prediction of Valproate in Chinese Epileptic Patients
Associated Prof Jiang , Dechun ; Bai , Xiangrong ; Zhang , Qingxia ; Prof. Lu , Wei ; Prof. Li , Lin ; Prof. Mueller , Markus (Beijing, China)
14.54-15.06
139
Spurious Immunoassay-Based Salicylate Identification In A Patient With Elevated Benzoic Acid Levels
Prof. Langman , Loralie ; Penn , Hannah ; Jannetto , Paul ; Aberle , Sara ; Crow , Sheri ; Sztajnkrycer , Mathew (Rochester Mn, United States of America)
15.06-15.18
196
Risk factors of isoniazid-induced hepatotoxicity in Tunisian tuberculosis patients
Ben Fredj, Nadia ; KERKENI, Emna ; GAM, Ryhem ; CHAABANE, Amel ; CHEDLY, Zohra ; BOUGHATTAS, Naceur ; AOUAM, Karim (Presenting author) (Monastir, Tunisia)
15.18-15.30
268
Metabolic ratios of venlafaxine and risperidone strongly predicts CYP2D6 genotype
PhD Haslemo, Tore ; Mannheimer, Buster ; Lindh, Jonatan ; Eliasson, Erik ; Molden, Espen (Oslo, Norway)

14.30-15.30
Pharmacometrics I

Mees Zaal

Michael Neely/Paula Shaiquevich (chairs)

14.30-14.42
011
Comparison of different vancomycin dose rates in premature neonates according to weight and serum creatinine values using a population pharmacokinetic approach.
Dr. Woillard , Jean-Baptiste ; Nolain , Patrick ; Casagrande , Kilian ; Lebreton , Vincent ; Neely , Michael ; Guigonis , Vincent ; Grine , Jamel ; Marquet , Pierre ; Saint-Marcoux , Franck (Limoges, France)
14.42-14.54
018
PHARMACOKINETIC MODELING ELUCIDATING THE RELATIONSHIPS BETWEEN EXPOSURE TO GANCICLOVIR AND ITS HEMATOTOXICITY IN ADULT RENAL TRANSPLANT RECIPIENTS.
Billat , Pierre-André ; Woillard , Jean-Baptiste ; Sauvage , François-Ludovic ; Essig , Marie ; Marquet , Pierre ; Picard , Nicolas ; Saint-Marcoux , Franck (Presenting author) (Limoges, France)
14.54-15.06
022
The quality of dosing recommendations during therapeutic drug monitoring of aminoglycosides at the Intensive Care Unit
Hurk, Godelief van den ; Janssen, J.M. ; Juffermans, N.P. ; Hest , Reinier van (Amsterdam, The Netherlands)
15.06-15.18
154
Nonlinear absorption pharmacokinetics of amoxicillin
Velde , Femke de ; Winter , Brenda de ; Koch , Birgit ; Gelder , Teun van ; Mouton , Johan (Rotterdam, The Netherlands)
15.18-15.30
218
Pharmacokinetics of morphine and the predictability of metabolite clearance through creatinine and albumin levels in terminally ill patients.
Franken, Linda ; Masman, A.D. ; Winter, B.C.M. de ; Koch, B.C.P. ; Baar, F.P.M. ; Tibboel, D. ; Gelder, T. van ; Mathot , Ron (Rotterdam, The Netherlands)

14.35-15.25
Poster Session IV

Willen Burger Foyer

Eric Franssen (chair)

14.35-14.40
026
The Analysis of Common Antiepileptic Drugs in Human Urine by LC-MS/MS
Carroll , Frances ; Lupo , Sharon ; Liang , Shun-Hsin ; Kahler , Ty ; Connolly , Paul (Bellefonte, U.S.A.)
14.40-14.45
133
Simultaneous determination of eight “new generation” antiepileptic drugs (AEDs) in serum by liquid chromatography tandem mass spectrometry (LC-MS/MS)
Mgr. Prochazkova, Petra (Frenstat pod Radhostem, Czech Republic)
14.45-14.50
259
LC/MS/MS Quantitative Analysis of Anticonvulsants and Antiepileptics in Urine, Oral Fluids and Serum, and Evaluation and Comparison of Sample Preparation Techniques
Dr. Doyle , Rory ; ph.d Szczesniewski , Andre ; ph.d Cote , Linda ; ph.d Frick , Lauren (Presenting author) (Hockessin, U.S.A.)
14.50-14.55
170
Rapid quantification of desfuroylceftiofur in different biological matrices after treatment of pigs with ceftiofur
Dr. Baumann, Sven ; Beyer, Anne ; Stahl, Jessica ; Scherz, Gesine ; Von Bergen, Martin ; Honscha, Walther ; Kietzmann, Manfred (Leipzig, Germany)
14.55-15.00
201
Evaluation of the pharmacometabolomic approach for developing TDM
Schmidt, Staffan (Stockholm, Sweden)
15.00-15.05
042
25B-NBOMe: Metabolism and Detectability of a new synthetic hallucinogen – studied by GC-MS, LC-MSn, and LC-HR-MSn
Caspar , Achim ; Meyer , Markus ; Maurer , Hans ; Brandt , Simon (Homburg, Germany)
15.05-15.10
004
An overview of the current state of analytical laboratory practices for therapeutic drug monitoring of immunosuppressants in Argentina
Schaiquevich , Paula ; Taich , Paula ; Riva , Natalia ; Mato , Gabriel ; Caceres Guido , Paulo (Buenos Aires, Argentina)
15.10-15.15
197
What is your policy if proficiency testing is not available Immuno-pharmacogenetic testing – Lymphocyte Toxicity Assay
Prof. Neuman , Manuela ; Nanau , Radu ; Dr. Cheema , Asim (Toronto, Canada)
15.15-15.20
096
MONITORING INFALMMATION – FIBROSIS IN ALCOHOLIC, NON-ALCOHOLIC AND VIRAL HEPATITIS
Prof. Neuman , Manuela ; Hilzenrat, Nir ; Cohen, Lawrence (Toronto, Canada)
15.20-15.25
150
TOXIC TOBRAMYCIN LEVELS AFTER TOBRAMYCIN INTAKE VIA SELECTIVE DECONTAMINATION OF THE DIGESTIVE TRACT (SDD)
Wassenaar , Sophie ; Brkic , Z. ; Dos Reis , Miranda ; Hunfeld , N.G.M. ; Koch , B.C.P. (Rotterdam, The Netherlands)

14.35-15.30
Poster Session V

Willen Burger Foyer

Vanessa Steenkamp (chair)

14.35-14.40
031
A New Challenge: Suicide Attempt using nicotine fillings for electronic cigarettes
MSc Brkic , Zina ; Schipper , E.M. ; Graaff , L.C.G. de ; Koch , B.C.P. ; Wilms , E.B. ; Alsma , J. ; Schuit , S.C.E. (Rotterdam, The Netherlands)
14.40-14.45
032
Trends in drug abuse consumption as assessed by drug screening in urine among Egyptians: An experience in drug abuse lab in Assiut University Hospital during the period 2007-2014.
Prof EL Desoky , Ehab S. ; Hamdy , Mostafa M ; Farghaly , H.a.n.a.n ; Ashry , E.s.r.a.a ; Taha , A.m.i.r.a ; Mulla , M.o.h.a.m (Assiut, Egypt)
14.45-14.50
034
Inhibition of paclitaxel metabolism by losartan and a losartan metabolite depends on CYP2C8 and CYP2C9 genotypes of human liver microsomes
Mukai, Yuji ; Toda, Takaki ; Eliasson, Erik ; Rane, Anders ; Inotsume, Nobuo (Otaru, Japan)
14.50-14.55
054
The Analysis of Fentanyl and Its Analogues in Human Urine by LC-MS/MS
Carroll , Frances ; Connolly , Paul (Presenting author); Lupo , Sharon ; Liang , Shun-Hsin ; Kahler , Ty (Bellefonte, U.S.A.)
14.55-15.00
058
In vitro Approach for the Placental Drug Transport Evaluation Model Using Induced Pluripotent Stem Cells
Dr. Ikeda, Kenji ; Miyaji, Aki ; Yoshimura, Kaho ; Ogawa, Masafumi ; Hirotani, Yoshihiko (Osaka, Japan)
15.00-15.05
067
Serum concentrations of eicosatrienoic acids in patients treated with and without angiotensin II receptor blockers
Senda , Asuna (Sapporo, Japan)
15.05-15.10
068
The inhibitory effect of statins and diclofenac on arachidonic acid metabolism in vitro
KATO, Yuka ; SAIKI, Shota ; MUKAI, Yuji ; TODA, Takaki ; ELIASSON, Erik ; RANE, Anders ; INOTSUME, Nobuo (Sapporo-shi Hokkaido, Japan)
15.10-15.15
081
Melanotan II skin-tanning drugs sold illegally on the internet: Poor manufacturing and challenges to public health
Breindahl, Torben ; Hindersson, Peter ; Kimergård, Andreas (Hjørring, Denmark)
15.15-15.20
089
A Multi-Class Drug and Metabolite Screen of 231 Analytes by LC-MS/MS
Carroll , Frances ; Lupo , Sharon ; Liang , Shun-Hsin ; Kahler , Ty ; Connolly , Paul (Presenting author) (Bellefonte, U.S.A.)
15.20-15.25
090
LC-MS/MS Method Development Challenges for the Separation of 43 Opioids and Metabolites
Carroll , Frances ; Lupo , Sharon ; Liang , Shun-Hsin ; Kahler , Ty ; Connolly , Paul (Bellefonte, U.S.A.)
15.25-15.30
095
Cannabis use in pregnancy and neonatal abstinence syndrome: a case report.
M.D. ELEFTHERIOU, GEORGIOS ; BUTERA, RAFFAELLA ; GALLO, MARIAPINA ; REBUTTI, ILARIA (Presenting author); BACIS, GIUSEPPE (BERGAMO, Italy)

14.35-15.30
Poster Session VI

Willen Burger Foyer

Iain Macphee (chair)

14.35-14.40
003
Tacrolimus substitution of commercial formulations in pediatric transplant patients
PhD student Riva , Natalia ; Dr. Cáceres Guido , Paulo ; Licciardone , Nieves ; Dr. Imventarza , Oscar ; Monteverde , Marta ; Staciuk , Raquel ; Charroqui , Alberto ; Mato , Gabriel ; Schaiquevich , Paula (Buenos Aires, Argentina)
14.40-14.45
006
Analysis of the variable factors in the blood tacrolimus concentration during the switch from continuous intraveneous infusion to oral administration after allogeneic hematopoietic stem cell transplantation
Suetsugu, Kimitaka ; Ikesue, H ; Uchida, M ; Yano, T ; Watanabe, H ; Yamada, T ; Kawashiri, T ; Kajiwara, M ; Miyamoto, T ; Shiratsuchi, M ; Egashira, N ; Masuda, S (Fukuoka, Japan)
14.45-14.50
012
Impact of CYP3A5 and ABCB1 genetic variants on blood exposure of and clinical responses to tacrolimus in patients with rheumatoid arthritis
Naito, Takafumi ; Mino, Yasuaki ; Aoki, Yuki ; Hirano, Kumi ; Shimoyama, Kumiko ; Ogawa, Noriyoshi ; Kagawa, Yoshiyuki ; Kawakami, Junichi (Hamamatsu, Japan)
14.50-14.55
016
PRE-TRANSPLANT TACROLIMUS EXPOSURE PREDICTS POST-TRANSPLANT DOSE REQUIREMENT
Shuker , Nauras ; Man , Femke de ; Weerd , Annelies de ; Agteren , Madelon van ; Weimar , Willem ; Betjes , Michiel ; Gelder , Teun van ; Hesselink , Dennis (Rotterdam, The Netherlands)
14.55-15.00
023
Rapid and combined measurement of tacrolimus, cyclosporin A, sirolimus and everolimus in whole blood and dried blood spot with LC-MS/MS
Ing. Egas , Annelies ; Maarseveen , Erik van (Utrecht, The Netherlands)
15.00-15.05
036
A comparative blind study between electrochemiluminescent immunoassay on 3 different analyzers and liquid chromatography-tandem mass spectrometry for tacrolimus monitoring.
phD Sampol , Emmanuelle ; Barthod , Lucie ; Guerber , Francoise ; Goldwirt , Laurianne ; Monard , Laetitia ; Lacarelle , Bruno (Marseille, France)
15.05-15.10
046
T-effector/T-regulatory balance as predictive biomarker of the risk of rejection and graft clinical outcome in liver transplant recipients
Hoyos, M ; Muro, M ; Rimola, A ; Navasa, M ; Miras, M ; Brunet, M (Barcelona, Spain)
15.10-15.15
047
Central memory regulatory T cells (CD4 CD25hiCD45RO CD62L ) predicts acute rejection in orthotopic liver transplant recipients along first month post-transplantation: a multicenter study
PhD Millan, Olga ; Boix, F ; San Segundo, D ; Muñoz, P ; Miras, M ; Rafael-Valdivia, L ; Rimola, A ; Fabrega, E ; Mrowiec, A ; Minguela, A ; Bolarin, JM ; Paz-Artal, E ; López-Hoyos, M ; Brunet, M ; Muro, M (Barcelona, Spain)
15.15-15.20
048
T Cell Function Monitoring after Allogeneic Stem Cell Transplantation: a useful tool for personalized Immunosuppression
PhD Millan, Olga ; Martinez, C ; Rovira, M ; Fernández-Avilés, F ; Lopez, A ; Suárez-Lledó, M ; Carreras, E ; Urbano-Ispízua, A ; Brunet, M (Barcelona, Spain)
15.20-15.25
051
Therapeutic drug monitoring (TDM) and adherence evaluation: complementary tools for the management of renal transplant patients
Dr Monchaud , Caroline ; Villeneuve , C. ; Essig , M. ; Coubret , A. ; Laroche , M.L. ; Lacroix , I. ; Bouchet , S. ; Merville , P. ; Kamar , N. ; Rousseau , A. ; Marquet , P. ; Woillard , Jean-Baptiste (Presenting author) (Limoges, France)
15.25-15.30
496
Evaluation of dihydropyrimidine dehydrogenase activity in plasma and saliva samples of colorectal cancer patients and its relation with the occurrence of toxicity
Prof. Linden, Rafael ; Galarza, Andrés ; Antunes, Marina ; Schwartsmann, Gilberto (Novo Hamburgo, Brazil)

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